PMID: 9547343May 23, 1998Paper

B-1 cell development: evidence for an uncommitted immunoglobulin (Ig)M+ B cell precursor in B-1 cell differentiation

The Journal of Experimental Medicine
Stephen H Clarke, L W Arnold

Abstract

Murine phosphatidyl choline (PtC)-specific B cells in normal mice belong exclusively to the B-1 subset. Analysis of anti-PtC (VH12 and VH12/Vkappa4) transgenic (Tg) mice indicates that exclusion from B-0 (also known as B-2) occurs after immunoglobulin gene rearrangement. This predicts that PtC-specific B-0 cells are generated, but subsequently eliminated by either apoptosis or differentiation to B-1. To investigate the mechanism of exclusion, PtC-specific B cell differentiation was examined in mice expressing the X-linked immunodeficiency (xid) mutation. xid mice lack functional Bruton's tyrosine kinase (Btk), a component of the B cell receptor signal transduction pathway, and are deficient in B-1 cell development. We find in C57BL/ 6.xid mice that VH12 pre-BII cell selection is normal and that PtC-specific B cells undergo modest clonal expansion. However, the majority of splenic PtC-specific B cells in anti-PtC Tg/xid mice are B-0, rather than B-1 as in their non-xid counterparts. These data indicate that PtC-specific B-0 cell generation precedes segregation as predicted, and that Btk function is required for efficient segregation to B-1. Since xid mice exhibit defective B cell differentiation, not programmed cell death, these...Continue Reading

References

Jan 1, 1992·International Reviews of Immunology·H H Wortis
Mar 1, 1990·European Journal of Immunology·P A Lalor, G Morahan
Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·R R Hardy, K Hayakawa
Nov 1, 1991·Immunology Today·A Kantor
Jul 1, 1990·The Journal of Experimental Medicine·C E CarmackR R Hardy
Jan 1, 1989·Advances in Immunology·T J Kipps
Jul 1, 1989·European Journal of Immunology·C A PennellS H Clarke
Sep 1, 1986·European Journal of Immunology·D KaragogeosH H Wortis
Oct 1, 1986·Immunological Reviews·L A HerzenbergL A Herzenberg
Apr 3, 1987·Science·R R HardyT Kishimoto
Jun 1, 1985·The Journal of Experimental Medicine·K HayakawaL A Herzenberg
Jul 26, 1984·The New England Journal of Medicine·F S RosenR J Wedgwood
Feb 1, 1981·The Journal of Experimental Medicine·J D TaurogA D Steinberg
Jan 1, 1983·The Journal of Experimental Medicine·K HayakawaL A Herzenberg
Apr 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·K HayakawaL A Herzenberg
Mar 1, 1982·The Journal of Experimental Medicine·H H WortisG Waneck
Sep 1, 1995·Immunity·W N KhanL A Herzenberg
Sep 1, 1995·Immunity·J D KernerR M Perlmutter
Feb 1, 1993·Immunology Today·G HaughtonS H Clarke
Dec 1, 1993·European Journal of Immunology·S H Clarke, S K McCray
Jan 1, 1993·Annual Review of Immunology·A B Kantor, L A Herzenberg
Dec 5, 1995·Proceedings of the National Academy of Sciences of the United States of America·S SatoT F Tedder
Aug 9, 1996·Science·M LeitgesA Tarakhovsky
Oct 1, 1996·Proceedings of the National Academy of Sciences of the United States of America·J S AndersonH H Wortis

❮ Previous
Next ❯

Citations

Dec 21, 2004·Springer Seminars in Immunopathology·Christoph J Binder, Gregg J Silverman
Nov 26, 2003·Antiviral Research·Mario U Mondelli
Feb 13, 2004·Gene·Boris Bartholdy, Patrick Matthias
Feb 11, 2003·Journal of Neuroimmunology·Shuang-Bao HuPhilip Gold
Apr 18, 2000·Experimental Gerontology·P GhiaA G Rolink
Jun 17, 2000·Current Opinion in Immunology·K Hayakawa, R R Hardy
Mar 14, 2000·Current Opinion in Immunology·I Su, A Tarakhovsky
Dec 17, 2003·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·M U Mondelli
Feb 6, 2004·Nature Immunology·Stefano CasolaKlaus Rajewsky
Nov 22, 2012·Proceedings of the National Academy of Sciences of the United States of America·Hongsheng WangHerbert C Morse
Aug 17, 1999·The Journal of Experimental Medicine·K P Lam, K Rajewsky
Feb 28, 2002·Annual Review of Immunology·Robert Berland, Henry H Wortis
Nov 18, 2015·Molecular Immunology·Lv-Yun ZhuJian-Zhong Shao
Dec 15, 2015·Annals of the New York Academy of Sciences·Eliver Eid Bou Ghosn, Yang Yang
Apr 2, 2003·Immunology·J RiggsR Chiasson
May 23, 2013·Annals of the New York Academy of Sciences·Thomas L RothsteinHiroaki Kaku
Aug 8, 2006·Autoimmunity Reviews·Byian Duan, Laurence Morel
Jan 9, 2007·Molecular Immunology·Cristina M ContrerasAnne B Satterthwaite
May 18, 2005·Journal of Lipid Research·Christoph J BinderJoseph L Witztum
Apr 26, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·M J ChumleyR R Hardy
Apr 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Akiko IkedaMasato Ikeda
May 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kosuke KataokaKohtaro Fujihashi
Feb 16, 2019·Science·Robin GrafKlaus Rajewsky
May 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dengping YinAnita S-F Chong
Oct 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·S XuK P Lam
Nov 9, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·H OhdanM Sykes
Dec 20, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·U KimR G Roeder
Feb 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·J J KennyD L Longo
Oct 21, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alan C WhitmorePatrick M Flood
Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·Y QianS H Clarke
Jun 19, 2002·The Journal of Biological Chemistry·Siew-Cheng WongKong-Peng Lam
Jul 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·H WangS H Clarke

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

B cell Differentiation

Depending on the signal received through the B cell receptor and other receptors, B cells differentiate into follicular or marginal zone B cells. Here is the latest research pertaining to this differentiation process.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis