B-50 (GAP-43) immunoreactivity is rarely detected within intact catecholaminergic and serotonergic axons innervating the brain and spinal cord of the adult rat, but is associated with these axons following lesion

Experimental Neurology
G AlonsoA Privat

Abstract

The persistence of high levels of B-50 (GAP-43) in fibers innervating various regions of the adult central nervous system is generally thought to characterize neuronal systems capable of undergoing morphological plasticity. In a recent series of in situ hybridization studies, it has been shown that most catecholaminergic and serotonergic neurons of the adult rat brain express high levels of B-50 mRNA. The present study addresses the question whether high expression of B-50 mRNA in the catecholaminergic and serotonergic perikarya corresponds with detectable high levels of the B-50 protein in the efferent axonal fibers that innervate various regions of the adult rat brain and spinal cord. For this purpose, vibratome sections were doubly immunostained for B-50 and for tyrosine hydroxylase or serotonin and were analyzed by laser scanning confocal microscope. Colocalizations were investigated either (1) in regions of intact rat brain and spinal cord in which particular concentrations of B-50 immunoreactive fibers appeared codistributed with catecholaminergic or serotonergic fibers or (2) in intrahypothalamic portions of the medial forebrain bundle in which a surgical lesion was made. In the intact brain, frequent colocalizations of ...Continue Reading

Citations

Jan 25, 2008·The European Journal of Neuroscience·Angela MüllnerMartin E Schwab
Nov 20, 2009·Expert Opinion on Therapeutic Targets·Simone Di Giovanni
Jul 25, 2013·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Ricco LindnerSimone Di Giovanni
Nov 4, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Simone Di GiovanniEric P Hoffman

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