PMID: 9447616Feb 3, 1998Paper

B-50, the growth associated protein-43: modulation of cell morphology and communication in the nervous system

Progress in Neurobiology
A B OestreicherL H Schrama

Abstract

The growth-associated protein B-50 (GAP-43) is a presynaptic protein. Its expression is largely restricted to the nervous system. B-50 is frequently used as a marker for sprouting, because it is located in growth cones, maximally expressed during nervous system development and re-induced in injured and regenerating neural tissues. The B-50 gene is highly conserved during evolution. The B-50 gene contains two promoters and three exons which specify functional domains of the protein. The first exon encoding the 1-10 sequence, harbors the palmitoylation site for attachment to the axolemma and the minimal domain for interaction with G0 protein. The second exon contains the "GAP module", including the calmodulin binding and the protein kinase C phosphorylation domain which is shared by the family of IQ proteins. Downstream sequences of the second and non-coding sequences in the third exon encode species variability. The third exon also contains a conserved domain for phosphorylation by casein kinase II. Functional interference experiments using antisense oligonucleotides or antibodies, have shown inhibition of neurite outgrowth and neurotransmitter release. Overexpression of B-50 in cells or transgenic mice results in excessive spro...Continue Reading

References

Sep 16, 1992·Biochemical and Biophysical Research Communications·E R Jap Tjoen SanP Schotman
Oct 1, 1992·Current Opinion in Neurobiology·K R Jessen, R Mirsky
Jul 1, 1992·Journal of Neurobiology·S M StrittmatterM C Fishman
Oct 1, 1992·Journal of Neurobiology·E W Dent, K F Meiri
Feb 1, 1992·Developmental Biology·K M StockerG Ciment
Mar 1, 1992·The Journal of Cell Biology·R CurtisK R Jessen
Jan 8, 1992·The Journal of Comparative Neurology·A A Dunn-MeynellB E Levin
Feb 1, 1992·Current Opinion in Cell Biology·R E Cheney, M S Mooseker
Jan 1, 1991·Molecular Neurobiology·A T Sim
Jan 1, 1991·Annals of the New York Academy of Sciences·J J NordenJ A Freeman
Jan 1, 1991·Neuroscience·J W DaniL I Benowitz
Sep 1, 1991·Journal of Neurobiology·J M Jacob, I G McQuarrie
Jan 30, 1992·Nature·J E Rothman, L Orci

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Citations

Jul 18, 2001·The Anatomical Record·S GeunaM G Giacobini-Robecchi
May 10, 2001·Hippocampus·A M Kleschevnikov, A Routtenberg
Jan 29, 2002·Journal of Neuroscience Research·Alexander SeitzEllen Heber-Katz
Feb 22, 2011·Naunyn-Schmiedeberg's Archives of Pharmacology·Emil TrofimiukJan J Braszko
Mar 25, 2010·Neuroscience Bulletin·Ping YangYu-Qin Yin
May 5, 2005·Experimental Neurology·Zhe YingFernando Gómez-Pinilla
May 4, 2001·Brain Research·J J López-CostaJ P Saavedra
Oct 18, 2000·European Journal of Pharmacology·R A Adan, W H Gispen
Feb 8, 2003·Experimental Eye Research·Francie E CoblentzSteven K Fisher
Aug 9, 2003·Neuropharmacology·Leon L Voronin, Enrico Cherubini
Sep 15, 2001·Mechanisms of Ageing and Development·T CasoliC Bertoni-Freddari
Feb 7, 2002·Trends in Pharmacological Sciences·Miao-Kun Sun, Daniel L Alkon
Mar 29, 2001·Neuroscience Research·V V Zakharov, M I Mosevitsky
Oct 21, 2000·Progress in Neurobiology·L M Garcia-SeguraL L DonCarlos
Jun 28, 2003·Biochimica Et Biophysica Acta·Vladislav V ZakharovMark I Mosevitsky
Jun 28, 2000·Neuroscience·D A HenzeG Barrionuevo
Aug 10, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Paul W AckermannAndris Kreicbergs
Mar 26, 2003·The Journal of Steroid Biochemistry and Molecular Biology·Maria Claudia Gonzalez DeniselleAlejandro F De Nicola
Dec 4, 2012·Acta Pharmacologica Sinica·Philippe M D'Onofrio, Paulo D Koeberle
Oct 1, 2003·Clinical and Experimental Pharmacology & Physiology·Lisa N Gillespie
Mar 12, 2002·The European Journal of Neuroscience·Jacob M MilikanStephen R Bolsover
Jul 9, 2002·The European Journal of Neuroscience·S HuloP Caroni
Jun 18, 2002·Journal of Neurochemistry·Arantxa TaberneroJosé M Medina
Jun 12, 2013·Proceedings of the National Academy of Sciences of the United States of America·Anna Letizia Allegra MascaroFrancesco S Pavone
Apr 10, 2002·Journal of Neurotrauma·Florencia LabombardaAlejandro F de Nicola

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