PMID: 9437706Jan 1, 1997Paper

B and C types natriuretic peptides modify norepinephrine uptake and release in the rat adrenal medulla

Peptides
M VattaB Fernández

Abstract

We have previously reported that atrial natriuretic factor (ANF) modulates adrenomedullar norepinephrine (NE) metabolism. On this basis, the aim of the present work was to study the effects of B and C types natriuretic peptides (BNP and CNP) on the uptake, intracellular distribution and release of 3H-NE. Experiments were carried out in rat adrenal medulla slices incubated "in vitro." Results showed that 100 nM of both, CNP and BNP, enhanced total and neuronal NE uptake. Both peptides (100 nM) caused a rapid increase in NE uptake during the first minute, which was sustained for 60 min. NE intracellular distribution was only modified by CNP (100 nM), which increased the granular fraction and decreased the cytosolic pool. On the other hand, spontaneous as well as evoked (KCl) NE release, was decreased by BNP and CNP (50 and 100 nM for spontaneous release and 1, 10, 50 and 100 nM for evoked output). The present results suggest that BNP and CNP may regulate catecholamine secretion and modulate adrenomedullary biological actions mediated by catecholamines, such as blood arterial pressure, smooth muscle tone, and metabolic activities.

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Citations

May 17, 2001·Current Hypertension Reports·J M Wyss, S H Carlson
Nov 7, 2001·Autonomic Neuroscience : Basic & Clinical·J T ChengM T Lin
Apr 7, 2007·Critical Care Medicine·Marjut VarpulaUNKNOWN FINNSEPSIS Study Group
Feb 22, 2005·Congestive Heart Failure·Andrew J Burger
Apr 11, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Megumi KoizumiHiroshi Ito
Sep 27, 2005·The Heart Surgery Forum·Nader Moazami, Mehmet C Oz
Jul 12, 2014·BioMed Research International·Marcelo Roberto ChoiBelisario Enrique Fernández
Oct 30, 2007·Regulatory Peptides·Alicia H CorreaBelisario E Fernández
Nov 17, 2004·Regulatory Peptides·Belisario E FernándezMarcelo R Choi
Jan 25, 2008·Progress in Neurobiology·Li-Hui Cao, Xiong-Li Yang
Dec 24, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Aldo ClericoMichele Emdin
Sep 17, 2003·The Journal of Pharmacology and Experimental Therapeutics·I-Min LiuJuei-Tang Cheng
Dec 19, 2001·American Journal of Physiology. Heart and Circulatory Physiology·Jean-Francois TolsaJ Usha Raj

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