B and T lymphocyte attenuator regulates T cell survival in the lung.

The Journal of Immunology : Official Journal of the American Association of Immunologists
Christine M DeppongJonathan M Green

Abstract

The initiation, intensity, and duration of T cell-directed inflammatory responses are dependent upon the coordination of both activating and inhibitory signals mediated by specific receptors on the T lymphocyte. The recently described receptor, B and T lymphocyte attenuator (BTLA), has been demonstrated to have an important role in limiting the duration of inflammation in a murine model of allergic asthma. In this study, we have examined the role of BTLA on the proliferation, recruitment, and survival of T cells in response to inhaled allergen. We find that there is decreased cell death in T cells from BTLA-deficient mice, whereas proliferation and recruitment to the lungs are unchanged. Thus, the regulation of cell death through BTLA signaling is a key determinant of the inflammatory response in the lung.

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Oct 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ran TaoWayne W Hancock
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Citations

Oct 18, 2011·American Journal of Physiology. Lung Cellular and Molecular Physiology·Christine M DeppongJonathan M Green
Oct 25, 2011·Immunological Reviews·Marcos W SteinbergCarl F Ware
Jan 12, 2017·Cell Communication and Signaling : CCS·Kemal CatakovicRoland Geisberger
Jul 2, 2009·Journal of Leukocyte Biology·Alison Crawford, E John Wherry
Jul 7, 2018·Allergy·Matthias FeuereckerAlexander Choukèr
May 6, 2010·European Journal of Immunology·Christine M DeppongJonathan M Green
Aug 10, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nacer-Eddine SerriariDaniel Olive
Jul 23, 2011·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Waka IshidaAtsuki Fukushima
Mar 24, 2010·Annual Review of Immunology·Theresa L Murphy, Kenneth M Murphy
Jun 6, 2009·Seminars in Immunopathology·Marcos W SteinbergMitchell Kronenberg
Oct 29, 2013·In Vitro Cellular & Developmental Biology. Animal·Yoshiaki AndoManabu Inobe
Sep 9, 2015·Frontiers in Immunology·Isabelle Le MercierRandolph J Noelle
Sep 12, 2018·Scientific Reports·Sandra RosskopfPeter Steinberger
Apr 17, 2021·Frontiers in Immunology·Zhaochen NingHuabao Xiong
Jun 25, 2021·Frontiers in Immunology·Zheng DengZheng Zheng
Dec 18, 2013·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Jonathan S BoomerJonathan M Green

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