B and T lymphocyte subsets enter peripheral lymph nodes and Peyer's patches without preference in vivo: no correlation occurs between their localization in different types of high endothelial venules and the expression of CD44, VLA-4, LFA-1, ICAM-1, CD2 or L-selectin

European Journal of Immunology
J WestermannR Pabst

Abstract

Many lymphocytes enter tissues such as peripheral lymph nodes, and Peyer's patches through high endothelial venules (HEV). It is known that HEV differ in the expression of adhesion molecules as lymphocyte subsets do. Through the interaction of these molecules B and T lymphocyte subsets are thought to be preferentially directed into lymphoid organs. However, it is unclear which role these mechanisms play in vivo, since there are no studies demonstrating that blood lymphocyte subsets preferentially interact with different types of HEV in vivo. Therefore, in the present study the frequency of B, T, CD4+ and CD8+ lymphocytes in the wall of the HEV of rat peripheral lymph nodes and Peyer's patches was analyzed by immunohistology. In addition, the expression of CD44, VLA-4, LFA-1, ICAM-1, CD2 and L-selectin on B and T lymphocyte subsets of the blood was determined by flow cytometry. Although B and T lymphocytes showed significantly different levels of expression for each adhesion molecule investigated, the relation of B and T lymphocytes within the HEV of peripheral lymph nodes and Peyer's patches was strikingly comparable (38.0 +/- 5.2% vs. 40.6 +/- 5.7% and 62.0 +/- 5.2% vs. 59.4 +/- 5.7%, respectively). The same was true for CD4+ ...Continue Reading

References

Nov 1, 1992·The Journal of Experimental Medicine·M BrusteinS R Watson
Jun 1, 1992·Current Opinion in Immunology·L J Picker
Aug 2, 1990·Nature·T A Springer
Feb 1, 1987·The Journal of Experimental Medicine·A F WilliamsA C Willis
Jan 1, 1993·Archives of Disease in Childhood·A Finn
Jan 1, 1993·Annual Review of Immunology·M P Bevilacqua

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Citations

Jun 1, 1996·Immunology Today·J Westermann, R Pabst
Aug 6, 2003·Nuclear Medicine and Biology·Alessandro FulgenziMaria Elena Ferrero
Jun 17, 1998·Scandinavian Journal of Immunology·M A ArriënsK C McCullough
May 17, 2014·PLoS Computational Biology·Vitaly V Ganusov, Jeremy Auerbach
Aug 17, 2014·Journal of Neuroimmunology·Amrita SinghKashi N Prasad
Aug 3, 1999·Journal of Neuroimmunology·S J Lee, E N Benveniste
May 18, 2000·Journal of Neuroimmunology·J P SmithS Amor
Jun 5, 2002·Journal of Neuroimmunology·Sarah FlorisHelga E De Vries
Nov 30, 2002·Journal of Neuroimmunology·Pasquale AnnunziataEugenio Paccagnini
Aug 1, 1997·Molecular Medicine Today·V H PerryH C Brown
Sep 1, 1996·Baillière's Clinical Gastroenterology·G KöhneM Zeitz
Jan 27, 2015·Trends in Immunology·Isioma U EgbuniweKatie E Lacy
Sep 27, 2008·The American Journal of Pathology·Tae NakasakiMasayuki Miyasaka
Oct 28, 1997·European Journal of Immunology·W Tietz, A Hamann
Mar 11, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·John GreenwoodPeter Adamson

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