B cell activating factor and T-helper 17 cells: possible synergistic culprits in the pathogenesis of Alopecia Areata

Archives of Dermatological Research
Mostafa Abou ElelaOlfat Shaker

Abstract

The role of T-helper 17 cells (Th17) and regulatory T-cells (Tregs) in the pathogenesis of alopecia areata (AA) has not been clearly elucidated. B cell activating factor (BAFF) being a regulator of T cell activation could be involved in this pathologic process as well. The current study evaluated the expression of IL-17, IL-22, Foxp3 and BAFF in tissue and sera of AA patients. Forty AA patients and 40 age and sex matched healthy controls were included. Tissue and serum levels of IL-17, IL-22, BAFF as well as serum level of Foxp3 were measured by enzyme-linked immunosorbent assay (ELISA). Immunohistochemical staining was used for assessment of tissue level of Foxp3. Tissue and serum levels of IL-17, tissue levels of IL-22 and BAFF were significantly higher in patients. Serum levels of IL-22, Foxp3 and BAFF were non-significantly higher in patients. Foxp3 immunostaining showed negativity in tissue of patients and controls. A significant positive correlation was found between both tissue levels of IL-17 and BAFF (r = 0.474, P = 0.035) and tissue level of IL-22 and disease duration (r = 0.766, P < 0.001) in AA patients. Th17 cells and BAFF are synergistically involved in the pathogenesis of AA. BAFF represents a promising therapeut...Continue Reading

References

Jun 1, 1990·The Journal of Investigative Dermatology·J AnselS Hefeneider
Jun 8, 1999·The Journal of Experimental Medicine·P SchneiderJ Tschopp
Jan 5, 2000·The Journal of Investigative Dermatology·C BodemerY De Prost
Nov 21, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·B HuardL E French
Jan 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wei-Ping MinRobert Zhong
Sep 5, 2003·Psychosomatics·A PicardiM Biondi
Sep 1, 2004·Journal of the American Academy of Dermatology·Elise A OlsenUNKNOWN National Alopecia Areata Foundation
Oct 16, 2004·Immunity·Jay K Kolls, Anders Lindén
Jan 20, 2005·The Journal of Experimental Medicine·Claire L LangrishDaniel J Cua
Apr 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrew P R SutherlandCharles R Mackay
Jan 3, 2006·The Journal of Allergy and Clinical Immunology·Johan VerhagenCezmi A Akdis
Jun 20, 2006·Immunity·Casey T WeaverKenneth M Murphy
Jun 22, 2006·Expert Reviews in Molecular Medicine·Wei LuKevin McElwee
Sep 20, 2006·The Journal of Experimental Medicine·Spencer C LiangLynette A Fouser
May 5, 2007·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Onno J de BoerMarcel B M Teunissen
Mar 11, 2008·Journal of Dermatological Science·Yoshihiro KuwanoKunihiko Tamaki
May 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Song Guo ZhengDavid A Horwitz
Jun 26, 2008·Proceedings of the National Academy of Sciences of the United States of America·Satoshi SeradaTetsuji Naka
Sep 18, 2008·The British Journal of Dermatology·K C MeyerR Paus
Sep 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Queenie Lai Kwan LamLiwei Lu
Nov 22, 2008·Journal of the American Academy of Dermatology·Pinar Y BasakVahide B Akkaya
Apr 4, 2009·Seminars in Cutaneous Medicine and Surgery·Seema Garg, Andrew G Messenger
May 13, 2009·The Journal of Investigative Dermatology·Ralf Paus, Petra Arck
Jul 27, 2010·BMJ : British Medical Journal·M J HarriesL E King
Jun 22, 2011·Dermatologic Therapy·Eddy Wang, Kevin J McElwee
Nov 26, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rajshekhar AlliTerrence L Geiger
Apr 20, 2012·The New England Journal of Medicine·Amos GilharRalf Paus
Feb 26, 2013·Journal of Dermatological Science·Bong Seok ShinAkimichi Morita
Apr 24, 2013·The British Journal of Dermatology·M K Tembhre, V K Sharma
May 18, 2013·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Bo ZhangTingting Su
Jul 11, 2013·Dermatology : International Journal for Clinical and Investigative Dermatology·Atsushi TanemuraIchiro Katayama
Aug 24, 2013·International Journal of Dermatology·Sarah TerrasJo Lambert
Sep 7, 2013·Dermatology : International Journal for Clinical and Investigative Dermatology·Genichi TojoSetsuya Aiba
Jan 15, 2014·Cytokine & Growth Factor Reviews·Maogen ChenSong Guo Zheng

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Citations

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