B cell-activating factor of the tumor necrosis factor family (BAFF) is expressed under stimulation by interferon in salivary gland epithelial cells in primary Sjögren's syndrome

Arthritis Research & Therapy
Marc IttahXavier Mariette

Abstract

B cell-activating factor (BAFF) has a key role in promoting B-lymphocyte activation and survival in primary Sjögren's syndrome (pSS). The cellular origin of BAFF overexpression in salivary glands of patients with pSS is not fully known. We investigated whether salivary gland epithelial cells (SGECs), the main targets of autoimmunity in pSS, could produce and express BAFF. We used quantitative RT-PCR, ELISA and immunocytochemistry in cultured SGECs from eight patients with pSS and eight controls on treatment with IL-10, tumor necrosis factor alpha (TNF-alpha), IFN-alpha and IFN-gamma. At baseline, BAFF expression in SGECs was low in pSS patients and in controls. Treatment with IFN-alpha, IFN-gamma and TNF-alpha + IFN-gamma increased the level of BAFF mRNA in pSS patients (the mean increases were 27-fold, 25-fold and 62-fold, respectively) and in controls (mean increases 19.1-fold, 26.7-fold and 17.7-fold, respectively), with no significant difference between patients and controls. However, in comparison with that at baseline, stimulation with IFN-alpha significantly increased the level of BAFF mRNA in SGECs of pSS patients (p = 0.03) but not in controls (p = 0.2), which suggests that SGECs of patients with pSS are particularly s...Continue Reading

References

Feb 1, 1993·Arthritis and Rheumatism·X MarietteJ P Clauvel
Jun 8, 1999·The Journal of Experimental Medicine·P SchneiderJ Tschopp
Dec 10, 1999·The Journal of Experimental Medicine·F MackayJ L Browning
Jul 6, 2000·Baillière's Best Practice & Research. Clinical Rheumatology·M N Manoussakis, H M Moutsopoulos
Oct 3, 2000·Human Pathology·S RegauerS Mannweiler
Oct 4, 2000·The Journal of Experimental Medicine·R K DoS Chen-Kiang
Oct 18, 2001·Current Opinion in Rheumatology·J A JamesR H Scofield
Jan 10, 2002·The Journal of Clinical Investigation·Joanna GroomFabienne Mackay
Mar 7, 2002·European Journal of Oral Sciences·Ioannis D DimitriouMenelaos N Manoussakis
May 15, 2002·Annals of the Rheumatic Diseases·C VitaliUNKNOWN European Study Group on Classification Criteria for Sjögren's Syndrome
Aug 3, 2002·Nature Immunology·Mikhail B LitinskiyAndrea Cerutti
Nov 13, 2002·Annual Review of Immunology·Fabienne MackayJeffrey Browning
Jan 15, 2003·Annals of the Rheumatic Diseases·X MarietteR Kimberly
Sep 10, 2003·Current Opinion in Rheumatology·Virginia PascualA Karolina Palucka
Jan 7, 2004·The Journal of Experimental Medicine·Brian P O'ConnorRandolph J Noelle
Oct 1, 2004·Arthritis and Rheumatism·Antigoni TriantafyllopoulouHaralampos M Moutsopoulos
Jan 26, 2005·American Journal of Respiratory Cell and Molecular Biology·Takechiyo YamadaAndrew Saxon
Apr 12, 2005·European Journal of Oral Sciences·Nicolas DelaleuMarkus M Koller
Apr 15, 2005·Molecular Immunology·Lai Guan NgFabienne Mackay
Jul 15, 2005·Annals of the New York Academy of Sciences·Jacques-Olivier PersPierre Youinou

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Citations

Nov 10, 2007·Clinical Reviews in Allergy & Immunology·Menelaos N Manoussakis, Efstathia K Kapsogeorgou
Nov 10, 2007·Clinical Reviews in Allergy & Immunology·Gikas E KatsifisSharon M Wahl
May 21, 2010·Mucosal Immunology·M E SternS C Pflugfelder
Jul 17, 2013·Nature Reviews. Rheumatology·Gaëtane Nocturne, Xavier Mariette
Oct 10, 2012·Proceedings of the National Academy of Sciences of the United States of America·John C HallAntony Rosen
Aug 22, 2008·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Kaushal S GandhiDavid R Booth
Jun 12, 2009·Rheumatology·A TyndallU Müller-Ladner
Feb 12, 2010·International Journal of Rheumatology·Luca QuartuccioSalvatore De Vita
Dec 1, 2010·Therapeutic Advances in Musculoskeletal Disease·Michael Voulgarelis, Athanasios G Tzioufas
Mar 5, 2011·Arthritis Research & Therapy·Cees G M KallenbergHendrika Bootsma
Mar 1, 2012·Arthritis Research & Therapy·Xavier Mariette
Jan 11, 2013·Arthritis Research & Therapy·Alexis Boneparth, Anne Davidson
Mar 26, 2013·Journal of Clinical Biochemistry and Nutrition·Fujimasa TadaMorikazu Onji
Dec 7, 2013·Molecular Therapy : the Journal of the American Society of Gene Therapy·N RoescherJacques-Eric Gottenberg
May 23, 2007·Proceedings of the National Academy of Sciences of the United States of America·Danila ValmoriMaha Ayyoub
Oct 31, 2006·Proceedings of the National Academy of Sciences of the United States of America·Jean S OakDavid A Fruman
Sep 1, 2007·Current Opinion in Rheumatology·Fabienne MackayStuart G Tangye
Jul 31, 2010·Current Opinion in Rheumatology·Xavier Mariette, Jacques-Eric Gottenberg
Sep 14, 2007·Scandinavian Journal of Gastroenterology·Martina FabrisElio Tonutti
Feb 26, 2014·Expert Review of Clinical Immunology·Frans G M KroeseHendrika Bootsma
Aug 9, 2011·Expert Opinion on Biological Therapy·Petra M MeinersHendrika Bootsma
Apr 5, 2011·Expert Opinion on Biological Therapy·Wan-Fai Ng, Simon J Bowman
Sep 5, 2015·BioMed Research International·Michal RihacekLenka Zdrazilova-Dubska
May 4, 2016·Proceedings of the National Academy of Sciences of the United States of America·Zhennan LaiJohn A Chiorini
Jul 15, 2016·Nature Reviews. Rheumatology·Alain SarauxValérie Devauchelle-Pensec
Aug 27, 2016·Immunologic Research·Radjiv GoulabchandPhilippe Guilpain
Apr 12, 2017·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Jeremy KiripolskyJill M Kramer
Jul 23, 2016·Immunologic Research·Andreas V Goules, Athanasios G Tzioufas
Dec 6, 2007·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Salvatore De VitaMartina Fabris
Feb 28, 2014·Annals of the Rheumatic Diseases·Xiang LinLiwei Lu
Jan 7, 2017·Scientific Reports·Anna-Carin LundellAnna Rudin
Jan 1, 2007·Women's Health·Ibtisam Al-Hashimi

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Methods Mentioned

BETA
biopsy
ELISA
PCR
FCS
biopsies

Software Mentioned

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