PMID: 9178071Jan 1, 1997Paper

B-cell activation versus tolerance--the central role of immunoglobulin receptor engagement and T-cell help

International Reviews of Immunology
D A Fulcher, A Basten

Abstract

The critical variables responsible for the decision between activation and tolerance in the B-cell compartment were studied in the well-characterised hen egg lysozyme:antilysozyme transgenic model. Mature B-cells exposed to a low antigenic signal, which resulted in a receptor occupancy of between 5% and 25%, remained 'indifferent' (i.e. were neither activated nor tolerant), had a normal lifespan and recirculated through B-cell follicles. When receptor occupancy reached a critical threshold of approximately 50%, the B-cells became activated and moved to the outer T-cell zones where they died. This threshold appeared to be lower in the case of immature B-cells. On addition of T-cell help, however, the B-cells were rescued, proliferated and secreted antibody. Thus the outcome of the interaction between B-cells and antigen (self or foreign) is determined largely by the degree of antigen receptor engagement and availability of T-cell help.

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Citations

Jun 17, 2000·Trends in Neurosciences·J J Archelos, H P Hartung
Oct 11, 2003·Autoimmunity Reviews·Philippe KrebsBurkhard Ludewig
Oct 19, 2007·Seminars in Immunopathology·Menna R Clatworthy, Kenneth G C Smith
Oct 20, 2010·Current Opinion in Immunology·Mark I Greene, Herman Waldmann
Apr 22, 2011·Blood·Daniel CorcosLouise S Matheson
Oct 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·Y TsujihataT Imoto
Nov 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sylvie GrégoireMartine Bruley Rosset
Jun 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael P Cancro, John F Kearney
Aug 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Suzanne C MorrisFred D Finkelman

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