B Cell Activity Is Impaired in Human and Mouse Obesity and Is Responsive to an Essential Fatty Acid upon Murine Influenza Infection

The Journal of Immunology : Official Journal of the American Association of Immunologists
Rasagna KosarajuSaame Raza Shaikh

Abstract

Obesity is associated with increased risk for infections and poor responses to vaccinations, which may be due to compromised B cell function. However, there is limited information about the influence of obesity on B cell function and underlying factors that modulate B cell responses. Therefore, we studied B cell cytokine secretion and/or Ab production across obesity models. In obese humans, B cell IL-6 secretion was lowered and IgM levels were elevated upon ex vivo anti-BCR/TLR9 stimulation. In murine obesity induced by a high fat diet, ex vivo IgM and IgG were elevated with unstimulated B cells. Furthermore, the high fat diet lowered bone marrow B cell frequency accompanied by diminished transcripts of early lymphoid commitment markers. Murine B cell responses were subsequently investigated upon influenza A/Puerto Rico/8/34 infection using a Western diet model in the absence or presence of docosahexaenoic acid (DHA). DHA, an essential fatty acid with immunomodulatory properties, was tested because its plasma levels are lowered in obesity. Relative to controls, mice consuming the Western diet had diminished Ab titers whereas the Western diet plus DHA improved titers. Mechanistically, DHA did not directly target B cells to eleva...Continue Reading

Associated Clinical Trials

References

Dec 13, 1985·JAMA : the Journal of the American Medical Association·D J WeberS M Lemon
Jun 12, 2002·Circulation·Henry C McGillUNKNOWN Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group
Jun 2, 2005·Nature Reviews. Immunology·Patrick Matthias, Antonius G Rolink
Jun 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christine A GoetzMichael A Farrar
Nov 30, 2005·The Journal of Experimental Medicine·Miriam Shapiro-ShelefKathryn Calame
Jan 30, 2007·Nature Reviews. Immunology·Renata Mazzucchelli, Scott K Durum
May 21, 2009·The British Journal of Nutrition·Michelle MicallefManohar Garg
Nov 17, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tatiana M Garcia-BatesRichard P Phipps
Dec 1, 2009·European Journal of Immunology·Kristina Rothaeusler, Nicole Baumgarth
Apr 16, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rajeshwari YogRobert S Chapkin
Oct 28, 2010·Nutrition Research Reviews·Niloofar Hariri, Louise Thibault
Dec 4, 2010·Experimental Biology and Medicine·Erik A Karlsson, Melinda A Beck
Dec 30, 2010·American Journal of Physiology. Endocrinology and Metabolism·Daniel A KaneRonald N Cortright
Jan 14, 2011·International Journal of Pediatric Obesity : IJPO : an Official Journal of the International Association for the Study of Obesity·T BurrowsM L Garg
Oct 26, 2011·International Journal of Obesity : Journal of the International Association for the Study of Obesity·P A SheridanM A Beck
Dec 20, 2011·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Benjamin Drew RockettSaame Raza Shaikh
May 2, 2012·International Journal of Obesity : Journal of the International Association for the Study of Obesity·R Huttunen, J Syrjänen
Jun 20, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sesquile RamonRichard P Phipps
Jul 31, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Joan ClàriaCharles N Serhan
Aug 18, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M Ete ChanClinton T Rubin
Nov 28, 2012·Journal of Leukocyte Biology·Eric A GurzellJenifer I Fenton
Mar 13, 2013·Proceedings of the National Academy of Sciences of the United States of America·Jason DeFuriaBarbara S Nikolajczyk
Aug 2, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·J Justin MilnerMelinda A Beck
Oct 23, 2013·European Journal of Pediatrics·Giulia GenoniGianni Bona
Nov 12, 2013·Cell Metabolism·Satoshi NishimuraRyozo Nagai
Jan 21, 2014·Experimental Gerontology·Daniela FrascaBonnie B Blomberg
Mar 25, 2014·Immunity·Christopher D BuckleyCharles N Serhan
Apr 4, 2014·American Journal of Physiology. Cell Physiology·Romain A ColasCharles N Serhan

❮ Previous
Next ❯

Citations

Nov 22, 2017·Annals of the American Thoracic Society·William D Green, Melinda A Beck
Feb 23, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Brita Kilburg-BasnyatKymberly M Gowdy
Jun 3, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christopher W FarnsworthRobert A Mooney
Mar 30, 2019·Journal of Travel Medicine·Rebekah Honce, Stacey Schultz-Cherry
Jun 26, 2017·Microbiome·Silvio D Pitlik, Omry Koren
Nov 23, 2019·Molecular Omics·J MolendijkM M Hill
Dec 15, 2019·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Flávia Márcia de Castro E SilvaAna Paula Ferreira
Jun 25, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Anandita PalSaame Raza Shaikh
Jun 11, 2020·Annual Review of Nutrition·Samuel Philip NobsEran Elinav
Mar 22, 2018·Frontiers in Immunology·Ioanna PettaMarkus Kleinewietfeld
Mar 22, 2018·Immunologic Research·Ina BährHeike Kielstein
Aug 16, 2018·The Journal of Clinical Investigation·Parker F DuffneyPatricia J Sime
Aug 19, 2020·International Journal of Molecular Sciences·Andreas RitterJuping Yuan
Jun 25, 2020·The FEBS Journal·Shuhei KobayashiYuji Owada
Jan 29, 2019·Toxicological Sciences : an Official Journal of the Society of Toxicology·Katelyn J SiegristAlison K Bauer
Apr 2, 2020·Frontiers in Immunology·Ina BährHeike Kielstein
Mar 3, 2020·Frontiers in Aging Neuroscience·Patrizia GiannoniNicola Marchi
Aug 29, 2020·BMC Biology·Christina ChuongJames Weger-Lucarelli
Sep 29, 2020·Frontiers in Immunology·Daniela Frasca, Bonnie B Blomberg
Jan 9, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Leonardo D Estrada, Stacey Schultz-Cherry
May 22, 2019·Immunology·Erick Esteves de OliveiraAna Paula Ferreira
Nov 23, 2017·The Journal of Biological Chemistry·E Madison SullivanSaame Raza Shaikh
Oct 27, 2020·Current Opinion in Pediatrics·Xingyuan FangSarah E Henrickson
Nov 30, 2020·BioFactors·Shayna Sandhaus, Andrew G Swick
Dec 25, 2019·Cold Spring Harbor Perspectives in Medicine·Rebekah HonceStacey Schultz-Cherry
Jan 20, 2021·Cellular and Molecular Life Sciences : CMLS·Aneesha Kulkarni, Laura W Bowers
Feb 9, 2021·Frontiers in Nutrition·Carlos O Mendivil
May 8, 2018·Biochimica Et Biophysica Acta. Biomembranes·Stephen R WassallSaame Raza Shaikh
Mar 4, 2021·Metabolites·Kristen J PolinskiJill M Norris
Aug 15, 2017·Molecular Aspects of Medicine·Charles N SerhanJesmond Dalli
Dec 2, 2017·The Journal of Nutritional Biochemistry·William GuesdonSaame Raza Shaikh
Apr 2, 2021·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Abrar E Al-ShaerSaame Raza Shaikh
Apr 4, 2021·International Journal of Molecular Sciences·Valeria GuglielmiPaolo Sbraccia
Apr 4, 2021·International Journal of Molecular Sciences·Franziska HornungStefanie Deinhardt-Emmer
Apr 8, 2021·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Angélica J M de LeeuwCornelis F Calkhoven
Apr 14, 2021·Journal of Leukocyte Biology·William D GreenSaame Raza Shaikh

❮ Previous
Next ❯

Related Concepts

Related Feeds

B cell Activation

B cell activation is initiated by the ligation of the B cell receptor with antigen and ultimately results in the production of protective antibodies against potentially pathogenic invaders. Here is the latest research.