Abstract
To investigate whether the increased rate of lymphocyte apoptosis in systemic lupus erythematosus is involved in the onset of the disease, apoptotic or necrotic T or B lymphocytes from various cell lines were injected intraperitoneally into pre-autoimmune (NZBxNZW)F1 mice (BW) and non-autoimmune BALB/c mice. The intraperitoneal production of cytokines and chemokines, the specific T cell response in the spleen, and the production of anti-histone and anti-dsDNA Ab were investigated. The onset of the disease was characterized by creatinine levels and evaluation of glomerular IgG deposits. In BW, but not in BALB/c mice, injection of apoptotic and not necrotic cells up-regulated IL-6 and IL-10 in resident macrophages. Administration of apoptotic cells augmented the number of Th2 and B lymphocytes recruited in the peritoneal cavity. Only the treatment with apoptotic B cells promoted a systemic Th2 autoimmune response to H2 histones, associated with earlier occurrence of high levels of anti-dsDNA autoantibodies, higher creatinine levels and more numerous glomerular IgG deposits than in BW controls not injected with apoptotic B cells. In genetically susceptible mice exposure to apoptotic of B, but not T, lymphocytes can elicit a Th2 re...Continue Reading
Citations
Sep 17, 2009·Journal of Clinical Immunology·Amir SharabiEdna Mozes
Jun 10, 2010·Journal of Clinical Immunology·Paul EggletonPaul G Winyard
Jan 23, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Michael J Ryan
May 1, 2004·Dermatology : International Journal for Clinical and Investigative Dermatology·Bernard Noël, Renato G Panizzon
Apr 5, 2013·PloS One·Zev SthoegerEdna Mozes
Feb 5, 2005·Arthritis and Rheumatism·Li DongDennis M Klinman
Apr 7, 2009·Journal of Autoimmunity·Zev M SthoegerEdna Mozes
Mar 13, 2009·Human Immunology·Zev M SthoegerEdna Mozes
Sep 11, 2009·Immunology·Hava Ben-DavidEdna Mozes
Aug 17, 2004·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Mariana J Kaplan
Feb 1, 2005·Joint, Bone, Spine : Revue Du Rhumatisme·Jérémie SellamAndré Kahan
Mar 1, 2006·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Amir SharabiEdna Mozes
Nov 1, 2005·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Micha J RapoportEdna Mozes
Jul 21, 2004·Rheumatic Diseases Clinics of North America·Philip L Cohen, Roberto Caricchio
Jul 22, 2014·Clinical and Experimental Immunology·K Fenton
Sep 20, 2015·Lupus·R K Nelson, K A Gould
Dec 1, 2007·Arthritis and Rheumatism·Der-Yuan ChenJoung-Liang Lan
Feb 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael F DennyMariana J Kaplan
Mar 14, 2017·Journal of Immunology Research·Yongkang WuLanlan Wang
Apr 15, 2020·Signal Transduction and Targeted Therapy·Ze Xiu XiaoSong Guo Zheng
Oct 10, 2006·International Journal of Immunopathology and Pharmacology·P StrattaR Pagni
Nov 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Claire GoulvestreFrédéric Batteux
Aug 25, 2015·Lupus Science & Medicine·Murray B UrowitzDaniel J Wallace
Apr 17, 2020·Signal Transduction and Targeted Therapy·Ze Xiu XiaoSong Guo Zheng