Jul 1, 2020

B Cell Control of Regulatory T Cells in Friend Virus Infection

Journal of Molecular Biology
Tyler C Moore, Kim J Hasenkrug


B lymphocytes have well-established effector roles during viral infections, including production of antibodies and functioning as antigen presenting cells (APC) for CD4 + and CD8+ T cells. B cells have also been shown to regulate immune responses and induce regulatory T cells (Tregs). In the Friend virus (FV) model, Tregs are known to inhibit effector CD8+ T cell responses and contribute to virus persistence. Recent work has uncovered a role for B cells in the induction and activation of Tregs during FV infection. In addition to inducing Tregs, B cell antibody production and APC activity is a target of Treg suppression. This review focuses on the dynamic interactions between B cells and Tregs during FV infection.

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Mentioned in this Paper

Regulatory T-Lymphocytes
Immune Response
CD8-Positive T-Lymphocytes
Virus Diseases
Antigen-Presenting Cells
Friend Murine Leukemia Virus
CD4 Positive T Lymphocytes