PMID: 6406639Jun 1, 1983Paper

B cell dependence on and response to accessory signals in murine lupus strains

The Journal of Experimental Medicine
G J Prud'hommeA N Theofilopoulos

Abstract

B cell hyperactivity, a feature common to all lupus-prone murine strains, may be caused by hyperresponsiveness to, overproduction of, or bypassing of certain signals required for B cell activation, proliferation, and differentiation. In this study, we have compared the responses of B cells from three lupus-prone strains of mice (BXSB males, MRL and NZB/W females) and normal strains in a number of assays for which two or more signals are required to obtain a response. In medium to low density cultures of B cells from BXSB and NZB/W but not MRL/l lupus mice, the cells' proliferation induced by bacterial lipopolysaccharide (LPS) or anti-mu antibody was much higher than that of B cells from normal controls. At low B cell density, polyclonal activation by these substances and subsequent Ig secretion were dependent on accessory signals present in supernatants of concanavalin A-treated normal lymphocytes (CAS) or on the MRL/l proliferating T cell-derived B cell differentiation factor (L-BCDF) in both lupus-prone and immunologically normal mice. However, the responses of B cells from BXSB and NZB/W, but not MRL/l, mice to these accessory signals were higher than those of normal mice. Ig synthesis by fresh B cells of BXSB and NZB/W mice...Continue Reading

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Citations

Dec 1, 1986·Agents and Actions·A N Theofilopoulos
Jan 1, 1986·Springer Seminars in Immunopathology·A N TheofilopoulosF J Dixon
Nov 26, 2009·Clinical Reviews in Allergy & Immunology·Subhrajit SahaElena Peeva
Jul 7, 1999·Journal of Reproductive Immunology·L M Senturk, A Arici
Nov 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·C L SidmanL D Shultz
Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·P A SingerA N Theofilopoulos
Oct 11, 1994·Proceedings of the National Academy of Sciences of the United States of America·D H KonoA N Theofilopoulos
Feb 1, 1985·The Journal of Experimental Medicine·D Wofsy, W E Seaman
Jul 1, 1985·The Journal of Experimental Medicine·A N TheofilopoulosF J Dixon
Mar 1, 1986·The Journal of Experimental Medicine·D J NoonanA N Theofilopoulos
Jun 1, 1987·The Journal of Experimental Medicine·D M Klinman, A D Steinberg
Apr 1, 1995·Immunological Reviews·D M Klinman, A D Steinberg
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Apr 1, 1986·European Journal of Immunology·V E KelleyT B Strom

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