B-cell epitopes of varicella-zoster virus glycoprotein II

Archives of Virology
A KjartansdóttirS R Norrby

Abstract

B-cell epitopes of varicella-zoster virus glycoprotein II were mapped by means of solid phase ELISA, synthetic oligopeptides (constructed according to the Davison-Scott sequencing of the varicella-zoster virus genome) and sera from varicellae and herpes zoster patients. The individual pattern of antibody peptide binding varied considerably but at least 9 more reactive sites seemed discernible. A 31-mer-peptide corresponding to a hydrophilic segment of the glycoprotein (aa 417-447) was constructed. This peptide reacted with 2 out of 4 varicellae and 5 out of 9 zoster sera, respectively.

References

Jan 1, 1991·Comparative Immunology, Microbiology and Infectious Diseases·R Manservigi, E Cassai
Sep 1, 1986·The Journal of General Virology·A J Davison, J E Scott
Jul 1, 1984·Journal of Clinical Microbiology·V A SundqvistB Wahren

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Citations

Apr 2, 2014·Reviews in Medical Virology·Mark Quinlivan, Judy Breuer
Sep 17, 2011·Expert Review of Vaccines·Mark QuinlivanD Scott Schmid

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