PMID: 873093May 1, 1977

B-cell function and blood glucose control in insulin dependent diabetics within the first month of insulin treatment

Diabetologia
O K Faber, Christian Binder

Abstract

Seventeen insulin dependent diabetics were studied after two to four weeks of insulin treatment in a situation approximating to their normal daily life. Some endogenous insulin secretion, assessed by plasma C-peptide determinations, was present in all. Plasma C-peptide concentration was positively correlated with the blood glucose concentration and increased after breakfast, lunch and dinner (p less than 0.01); both peak values and relative increases were lower than those observed in normal subjects (p less than 0.01). The highest insulin secretory capacity was found in subjects with the least unstable blood glucose concentration (r=0.57, p less than 0.03), and these patients required the smallest insulin doses (r=0.54, P less than 0.04). These findings demonstrate the metabolic importance of a preserved B-cell function.

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Citations

Sep 1, 1994·Diabetologia·J WahrenH Wallberg-Henriksson
Jan 1, 1979·Diabetologia·A B KurtzJ D Nabarro
Nov 1, 1979·Diabetologia·P McNairI Transbøl
Nov 1, 1979·Diabetologia·T LauritzenC Binder
Jan 13, 2006·Diabetologia·E B TsaiKevan C Herold
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Related Concepts

Teens
Antigens
Blood Glucose
C-Peptide
Diabetes Mellitus
Dose-Response Relationship, Drug
Ingestion
Insulin B Chain
Pancreas

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