B-cell helper T cells and type 1 diabetes

Scandinavian Journal of Immunology
Céline Vandamme, Tuure Kinnunen

Abstract

Type 1 diabetes is an autoimmune disease typically starting in childhood that culminates in the destruction of insulin-producing beta cells in the pancreas. Although type 1 diabetes is considered to be a primarily T-cell mediated disease, B cells clearly participate in the autoimmune process, as autoantibodies recognizing pancreatic islet antigen commonly appear in circulation before the onset of the disease. T cells providing helper functions to B cells have recently been shown to be involved in the pathogenesis of a wide range of antibody-associated immune disorders. These T cells include CXCR5-positive follicular T helper (Tfh) cells and a recently described closely related CXCR5-negative subset coined peripheral T helper (Tph) cells. Here, we review the current state of knowledge on different B-cell helper T cell subsets, focusing on their potential involvement in the development of type 1 diabetes.

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Methods Mentioned

BETA
flow cytometry
transgenic

Clinical Trials Mentioned

NCT02443155

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