B cell lymphoma-associated hemophagocytic syndrome after PBSCT

Bone Marrow Transplantation
T TakahashiY Yazaki

Abstract

Hemophagocytic syndrome (HPS) associated with T cell lymphoma is well known, but an association with B cell lymphoma is rare. We report a patient who developed subcutaneous non-Hodgkin's lymphoma (NHL) of B cell origin. Autologous peripheral blood stem cell transplantation (PBSCT) was undertaken in her second complete remission (CR), but HPS appeared 5 months after transplantation. The patient deteriorated rapidly and died of metabolic acidosis. Necropsy revealed that she had relapsed B cell NHL involving liver, spleen and bone marrow. B cell NHL after PBSCT, associated with HPS as an initial sign, is rare. We report this case and review the literature.

Citations

May 7, 2003·International Journal of Hematology·Tatsuharu OhnoUNKNOWN Kyoto University Hematology/Oncology Study Group
Jan 30, 2004·Journal of Internal Medicine·S HasselblomB Ridell
Aug 28, 2009·British Journal of Haematology·Shinsuke TakagiShuichi Taniguchi
Aug 27, 2005·Oncogene·Jonas Larsson, Stefan Karlsson
Aug 27, 2005·Oncogene·Hui-Kuan LinPier Paolo Pandolfi
May 16, 2000·Leukemia & Lymphoma·C ShimazakiM Nakagawa
Aug 8, 2002·Oncogene·Olena PreobrazhenskaSerhiy Souchelnytskyi
Jul 27, 2004·Oncogene·Jan BrábekSteven K Hanks
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