B-cell lymphoma mutations: improving diagnostics and enabling targeted therapies

Haematologica
J P VaquéMiguel A Piris

Abstract

B-cell lymphomas comprise an increasing number of clinicopathological entities whose characterization has historically been based mainly on histopathological features. In recent decades, the analysis of chromosomal aberrations as well as gene and miRNA expression profile studies have helped distinguish particular tumor types and also enabled the detection of a number of targets with therapeutic implications, such as those activated downstream of the B-cell receptor. Our ability to identify the mechanisms involved in B-cell lymphoma pathogenesis has been boosted recently through the use of Next Generation Sequencing techniques in the analysis of human cancer. This work summarizes the recent findings in the molecular pathogenesis of B-cell neoplasms with special focus on those clinically relevant somatic mutations with the potential to be explored as candidates for the development of new targeted therapies. Our work includes a comparison between the mutational indexes and ranges observed in B-cell lymphomas and also with other solid tumors and describes the most striking mutational data for the major B-cell neoplasms. This review describes a highly dynamic field that currently offers many opportunities for personalized therapy, a...Continue Reading

References

Jun 8, 2015·Current Opinion in Hematology·Goldi A Kozloski, Izidore S Lossos
Oct 29, 2015·Cellular and Molecular Life Sciences : CMLS·Yana R MusinovaYegor S Vassetzky
Apr 4, 2015·Seminars in Cancer Biology·Annunziata Gloghini, Italia Bongarzone
Jul 16, 2015·Genes, Chromosomes & Cancer·Rabea Wagener"Molecular Mechanisms in Malignant Lymphomas" Network Project of the Deutsche Krebshilfe
Feb 3, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Hossein RahimiShaghayegh Rahmani
Apr 19, 2016·Leukemia & Lymphoma·Nataliya MarMark E Dailey
Feb 26, 2016·Expert Review of Hematology·Naval DaverFarhad Ravandi
Jun 7, 2016·Journal of Genetic Counseling·Morgan SimilukMichael Lenardo
Sep 7, 2016·The Journal of Investigative Dermatology·María Del Carmen González-VelaJ P Vaqué
Mar 10, 2017·Expert Opinion on Drug Discovery·Gillian A Horne, Mhairi Copland
Dec 17, 2017·Oncotarget·Estíbaliz Tamayo-OrbegozoSusana Larrucea
Sep 4, 2018·Cancer Biomarkers : Section a of Disease Markers·Lan DengXiuju Wang
Oct 16, 2018·Frontiers in Immunology·Gail A BishopBruce S Hostager
May 26, 2017·Biomedicines·Laura D'IgnazioSonia Rocha
Jun 13, 2018·Journal of Translational Medicine·Jeong Mi YangJin Ho Paik
May 21, 2020·Current Hematologic Malignancy Reports·Saman KhanAmmar Chaudhry
Aug 15, 2017·Gene Therapy·F Carrasco-RamiroB Aguado
Jul 16, 2020·Cancers·Antonio Giovanni SolimandoDomenico Ribatti

Citations

Dec 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·Riccardo Dalla-FaveraC M Croce
Jan 5, 2000·Proceedings of the National Academy of Sciences of the United States of America·Y ShouW Michael Kuehl
Jan 3, 2001·The New England Journal of Medicine·H DöhnerPeter Lichter
Oct 19, 2001·Oncogene·P Leif Bergsagel, W Michael Kuehl
Apr 19, 2002·Biochimica Et Biophysica Acta·Werner LutzMartin Eilers
Jun 18, 2002·Nature·Helen DaviesP Andrew Futreal
Jun 21, 2002·The New England Journal of Medicine·Andreas RosenwaldLymphoma/Leukemia Molecular Profiling Project
Oct 24, 2002·Blood·Margarita Sánchez-BeatoMiguel A Piris
Apr 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·Nicole Y FangJoseph G Hacia
Jun 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·Zirong LiBing Ren
Dec 3, 2005·Leukemia & Lymphoma·Manoela M OrtegaCarmen S P Lima
Nov 10, 2006·Proceedings of the National Academy of Sciences of the United States of America·Karen I ZellerChia-Lin Wei
Dec 13, 2006·ChemMedChem·Zhengying PanJames T Palmer
Mar 6, 2007·Cytokine & Growth Factor Reviews·Eva V Acosta-RodríguezAdriana Gruppi
May 15, 2007·Oncogene·A G TurjanskiJ S Gutkind
Jul 6, 2007·Leukemia·A RodríguezSpanish National Cancer Centre (CNIO)
Aug 19, 2007·Cancer Cell·Jonathan J KeatsP Leif Bergsagel
Apr 16, 2008·British Journal of Haematology·Pedro Jares, Elías Campo
Apr 11, 2009·Nature·Michael R StrattonP Andrew Futreal
Apr 16, 2010·Nature·Thomas J HudsonHuanming Yang
Oct 5, 2010·Cancer Research·K-John J CheungDouglas E Horsman
Oct 19, 2010·Developmental Cell·Duojia Pan
Dec 24, 2010·Nature·Vu N NgoLouis M Staudt
Jan 18, 2011·Hematology·Thomas E Witzig, Mamta Gupta
Mar 11, 2011·Nature·Laura PasqualucciRiccardo Dalla-Favera
Mar 25, 2011·Nature·Michael A ChapmanTodd R Golub
Jun 15, 2011·The New England Journal of Medicine·Enrico TiacciBrunangelo Falini
Jul 29, 2011·Nature·Ryan D MorinMarco A Marra
Aug 2, 2011·Nature Genetics·Laura PasqualucciRiccardo Dalla-Favera

Related Concepts

Pathogenic Aspects
Gene Expression Regulation, Neoplastic
Pathogenesis
Somatic Mutation
Neoplasms
RNA, Small Temporal
B-Lymphocytes
Autosome Abnormalities
Massively-Parallel Sequencing
RNA, Neoplasm

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