PMID: 6982184Sep 1, 1982Paper

B cell lymphoproliferation in spontaneously diabetic BB Wistar rats

Diabetologia
T A SeemayerN Kalant

Abstract

Ninety-six spontaneously diabetic BB Wistar rats were maintained for their natural life span and, at death, were autopsied together with 86 age-and sex-matched non-diabetic BB control rats. A 15% incidence of abdominal B cell lymphoproliferative lesions was documented in the diabetic rats compared with 1% incidence in the non-diabetic rats (p less than 0.005). The B cell lymphoproliferative process included minute mesenteric and omental aggregates of plasma cells and small lymphocytes (one rat), atypical partially fibrotic lymphoproliferative mesenteric nodules (three rats), and malignant lymphoma with features of immunoblastic sarcoma (eight rats) or plasma cell lymphoma (two rats). Cytoplasmic immunoglobulin was demonstrated in two of the four lymphomas examined by the peroxidase-antiperoxidase technique, thus confirming their B cell derivation. The striking incidence of B cell lymphoproliferation in this diabetic population is additional evidence of altered immunity in this animal model of insulin-dependent diabetes mellitus.

References

Mar 29, 1979·The New England Journal of Medicine·B J Sullivan
Dec 1, 1973·Journal of Maxillofacial Surgery·W R Koberg
Oct 1, 1974·Cancer·R J Lukes, R D Collins
Oct 1, 1981·Diabetes·R JacksonG S Eisenbarth

❮ Previous
Next ❯

Citations

Oct 1, 1986·Mechanisms of Ageing and Development·J R WrightA J Yates
May 1, 1993·The Journal of Pathology·C J MeehanJ D Baird
Dec 15, 1986·Klinische Wochenschrift·U Bicker, K H Usadel
Feb 1, 1986·European Journal of Immunology·H KolbU Kiesel
Jul 1, 1987·Diabetes/metabolism Reviews·J P MordesA A Rossini
May 7, 1999·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·K HehenbergerK Brismar

❮ Previous
Next ❯

Related Concepts

Related Feeds

B cell Differentiation

Depending on the signal received through the B cell receptor and other receptors, B cells differentiate into follicular or marginal zone B cells. Here is the latest research pertaining to this differentiation process.

Related Papers

The New England Journal of Medicine
B J Sullivan
European Journal of Immunology
Stefan H E Kaufmann, Astrid Hahner
Metabolism: Clinical and Experimental
P PoussierE B Marliss
© 2021 Meta ULC. All rights reserved