Nov 8, 2018

B Cell Receptor Crosslinking Augments Germinal Center B Cell Selection when T Cell Help Is Limiting

Cell Reports
Jackson Steed TurnerIrina Leonidovna Grigorova

Abstract

Antigen-dependent engagement of germinal center (GC) B cell receptors (BCRs) promotes antigen internalization and presentation for follicular helper T cells. However, whether BCR signaling is critical or synergistic with T cell help for GC B cell selection or differentiation is unclear. Here, by adapting an experimental approach that enables independent delivery of BCR-crosslinking antigen or T cell help to GC B cells in vivo, we showed that T cell help was sufficient to induce GC B cell expansion and plasmablast formation. However, although BCR crosslinking could not by itself promote GC B cell selection or differentiation, it could synergize with T cell help to enhance the GC and plasmablast responses when T cell help was limiting. These findings indicate that GC B cells can integrate variable inputs from T cell help and BCR signaling in vivo for an optimal process of selection and differentiation, critical for potent long-term humoral immunity.

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Mentioned in this Paper

In Vivo
T-Lymphocyte
Structure of Germinal Center of Lymph Node
Malignant Neoplasm of Stomach
Receptors, Antigen, B-Cell
Plasmablast (Cell)
Receptors, Cell Surface
Humoral Immunity
B Cell Selection
Cell Differentiation Process

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