B cell repopulation kinetics after rituximab treatment in ANCA-associated vasculitides compared to rheumatoid arthritis, and connective tissue diseases: a longitudinal observational study on 120 patients

Arthritis Research & Therapy
Jens ThielNils Venhoff

Abstract

B cell depletion with rituximab (RTX) is approved for treatment of rheumatoid arthritis (RA) and ANCA-associated vasculitides (AAV). Recently, RTX has been shown to be effective in AAV maintenance therapy, but an optimal RTX treatment schedule is unknown and the time to B cell repopulation after RTX has not been studied. Retrospective single-center analysis of B cell repopulation in patients with AAV, RA or connective tissue disease (CTD) treated with RTX. Beginning B cell repopulation within the first year after RTX treatment was observed in 93% of RA and 88% of CTD patients. Only 10% of patients with granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) and no patient with eosinophilic granulomatosis with polyangiitis (EGPA) showed B cell repopulation within this time. Median time of B cell depletion was 26 months in GPA/MPA, and 21 months in EGPA compared to 9 months in RA, and 8 months in CTD (p < 0.0001). In 25 AAV-patients B cell depletion lasted for at least 44 months. There was a significant decline in serum immunoglobulin concentrations in GPA/MPA patients, but not in patients with RA or CTD. Significantly more GPA/MPA patients developed hygogammaglobulinemia (IgG <7 g/L) compared to patients with R...Continue Reading

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Citations

Apr 28, 2019·Expert Opinion on Biological Therapy·Mihai AncauBernhard Hemmer
Jun 21, 2018·Annals of the Rheumatic Diseases·Sergey V MoiseevPavel I Novikov
Feb 19, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sarah StablerVincent Sobanski
Sep 1, 2018·International Journal of Rheumatic Diseases·Durga P MisraAman Sharma
Jan 4, 2020·Clinical Rheumatology·Marta Casal MouraMisbah Baqir
Aug 16, 2018·Nature Reviews. Rheumatology·Mark McClureRachel Jones
Jul 14, 2019·Journal of Nephrology·Martina TedescoFederico Alberici
Dec 13, 2019·Arthritis Research & Therapy·Doris UrlaubWolfgang Merkt
Aug 8, 2020·Clinical and Experimental Nephrology·Shinya TaguchiShuzo Kobayashi
Nov 18, 2018·Nature Reviews. Nephrology·Kristine OleinikaAlan D Salama
May 28, 2019·Frontiers in Pediatrics·Mahmoud KallashJohn D Mahan
Nov 30, 2019·ACR Open Rheumatology·Chace MitchellRandy Q Cron
Nov 6, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Gemma D BanhamLorraine Harper
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Jun 1, 2021·Frontiers in Immunology·Joanna TieuDavid R W Jayne
May 5, 2021·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Annette BruchfeldWladimir M Szpirt

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Methods Mentioned

BETA
flow cytometry

Software Mentioned

GraphPad Prism

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