B cell responses to H5 influenza HA in human subjects vaccinated with a drifted variant.

Vaccine
Jane BaerDavid J Topham

Abstract

B cell responses after immunization with a drifted H5 influenza/A/Vietnam/1203/04 vaccine were characterized in the peripheral blood of human subjects primed with experimental recombinant H5 influenza A/Hong Kong/156/97 vaccine. Antibody secreting cells were assayed by ELISPOT against a panel of recombinant hemagglutinin and control proteins. Increased frequencies of H5 HA-specific antibody secreting and memory B cells could be observed within 7 days of re-vaccination. Furthermore, these responses were cross-reactive to both H5 HA variants, but not H3 or avian H6 HA strains. These observations suggest prior vaccination against H5 influenza HA induces cellular immune responses that cross-react among drifted variants, without precluding a response to new, or existing HA strains.

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Citations

Sep 21, 2011·The Journal of Infectious Diseases·Anuja MathewAlan L Rothman
Sep 13, 2012·The Journal of Infectious Diseases·Rishi Delan PathiranaRebecca Jane Cox
Dec 18, 2010·Expert Review of Vaccines·Nikolai Petrovsky, Ted M Ross
Nov 8, 2014·The Journal of Infectious Diseases·Jennifer L NayakAndrea J Sant
Feb 16, 2018·Journal of Virology·Sinthujan JegaskandaKanta Subbarao

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