PMID: 11913944Mar 27, 2002Paper

B cell signaling. Introduction

International Reviews of Immunology
Takeshi Tsubata, J Wienands

Abstract

The B cell antigen receptor (BCR) is composed of the membrane form of the immunoglobulin (Ig) and the Ig-alpha/Ig-beta heterodimer, which function as the antigen recognition component and the signaling component, respectively. A signal transmitted by BCR modulates gene expression, adhesion or survival, thereby determining the fate of antigen-encountered B cells. BCR proximal signaling occurs within cholesterol- and sphingolipid-rich plasma membrane microdomains termed lipid rafts, and involves tyrosine kinases such as Lyn, Syk and Btk and the adapter molecule SLP65/BLNK. Although the distal signaling cascades via BCR are not yet fully elucidated, various components are already identified, such as lipid kinases and small G-proteins. BCR signaling is regulated by various membrane molecules termed co-receptors such as CD19 and CD22. The BCR co-receptors appear to be required for normal immune functions. Viral proteins such as LMP2 also regulate BCR signaling to maintain viral latency. Various aspects of BCR signaling and its regulatory mechanisms are discussed in this issue.

References

Mar 27, 2002·International Reviews of Immunology·J Wienands, N Engels
Mar 27, 2002·International Reviews of Immunology·L B Justement
Mar 27, 2002·International Reviews of Immunology·J C PoeT F Tedder
Mar 27, 2002·International Reviews of Immunology·S J McLeod, M R Gold
Mar 27, 2002·International Reviews of Immunology·M MerchantS K Pierce

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Citations

Jul 21, 2007·The Journal of Biological Chemistry·Valerie Chew, Kong-Peng Lam
May 31, 2003·Nature Reviews. Drug Discovery·Josef S Smolen, Günter Steiner
Dec 22, 2005·Nature Immunology·Brian E CollinsJames C Paulson
May 24, 2012·Leukemia & Lymphoma·Matthew S Davids, Jennifer R Brown
Jan 6, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Manabu FujimotoShinichi Sato
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Mar 17, 2018·Journal of the American Heart Association·Aya FurushoYoshihiro Fukumoto
Nov 14, 2003·The Journal of Biological Chemistry·Ralph KettritzFriedrich C Luft
Mar 28, 2019·Expert Review of Hematology·Marina DeodatoAlessandra Tedeschi
Jan 31, 2006·Cancer Letters·Peter J Coopman, Susette C Mueller

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