B-cell stimulation

Current Opinion in Immunology
R J Armitage, M R Alderson

Abstract

Recent studies have identified CD40 ligand (CD40L) as the critical membrane-expressed molecule responsible for T cell dependent B-cell activation. CD40L co-operates with various cytokines to induce B-cell activation, proliferation, and immunoglobulin isotype switching. Some antigens, however, can also stimulate B-cell activation and isotype switching in the absence of CD40L or T cells. Recent studies have suggested that cytokines derived from non-T cells, such as natural killer cells, macrophages and mast cells, are responsible for isotype switching in T cell independent responses.

References

May 7, 1992·Nature·R J ArmitageC R Maliszewski
Jul 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·R J NoelleA Aruffo
Sep 6, 1991·Cell·D CosgroveD Mathis
Nov 22, 1990·Nature·P Aldhous, S Shulman
Jan 1, 1981·The Journal of Experimental Medicine·P K MonginiW E Paul
Nov 1, 1993·Immunology Today·R E CallardM K Spriggs
Aug 1, 1994·Immunity·J XuR A Flavell
Jun 1, 1994·Current Opinion in Immunology·R J Armitage
Nov 1, 1994·The Journal of Experimental Medicine·B R RenshawC R Maliszewski
Feb 3, 1994·Nature·E A Clark, J A Ledbetter
Feb 1, 1994·The Journal of Experimental Medicine·F BrièreJ Banchereau
Jan 1, 1993·Immunology Today·C M Snapper, J J Mond
Jan 1, 1993·Annual Review of Immunology·D C Parker

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Citations

Dec 10, 2003·International Journal of Pediatric Otorhinolaryngology·P Brandtzaeg
Jun 8, 1999·The Journal of Experimental Medicine·P SchneiderJ Tschopp
Aug 10, 1997·AIDS Research and Human Retroviruses·K C WolthersL Meyaard
Nov 5, 1999·Current Opinion in Oncology·R A Baiocchi, M A Caligiuri
Apr 16, 1999·Journal of Pediatric Gastroenterology and Nutrition·S H MurchJ A Walker-Smith
May 23, 2002·Transplantation·Michael A ReesPeter J Friend
Aug 2, 2003·Biochemical and Biophysical Research Communications·Hidetoshi KumagaiToshio Kitamura
May 22, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·H S KangI Choi
Jun 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Felix BischofAda M Kruisbeek
Aug 22, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Daria DonatiMaria Teresa Bejarano
Jun 22, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·K NatarajanK V Rao
Dec 19, 2020·Scientific Reports·Adil S Al-OgailiYoung Min Kwon

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