B-cell subsets in blood and lymphoid organs in Macaca fascicularis

Cytometry. Part a : the Journal of the International Society for Analytical Cytology
Yulia VugmeysterK McKeever

Abstract

Cynomolgus monkeys (Macaca fascicularis) are widely used animal models in biomedical research. However, the phenotypic characteristics of cynomolgus monkey (CM) B cells in peripheral blood (PB) and lymphoid organs are poorly understood. FACS analyses of PB-, spleen-, lymph node (LN)-, and bone marrow (BM)-derived B cells were performed. CM peripheral blood B cells have a smaller fraction of CD27(-) (naive) cells ( approximately 40%), as compared to human blood samples ( approximately 70%). Similar to humans, an early activation marker, CD23, is expressed more on CD27(-) CM naive B cells, as compared to CD27(+) B cells. The mean fraction of B cells exhibiting a memory phenotype is similar to that seen in human blood. Unlike humans, CM blood contains a subset of CD20(++)CD80(+)CD21(-)IgM(+/-)CD27(+)CD19(+)FSC(++)BAFF-R(low) B cells that are likely of germinal center origin. Thus, CM blood contains (i) a higher percentage of B cells that express the co-stimulatory molecule CD80, and (ii) a lower fraction of B cells that are CD21(+), as compared to human blood. Due to the relative paucity of information on B-cell subsets in organs of healthy humans, a direct comparison between human and CM lymphoid organ data is limited. The fracti...Continue Reading

References

Feb 1, 1992·The Journal of Pediatrics·F M Erkeller-YukselF Vanlangendonck
Sep 1, 1994·Clinical Immunology and Immunopathology·B Fernández-GutiérrezJ A Jover
Apr 1, 1997·Immunological Reviews·Y J Liu, C Arpin
Nov 6, 1998·The Journal of Experimental Medicine·S G TangyeJ E de Vries
Nov 24, 1999·The Journal of Laboratory and Clinical Medicine·A K Gopal, O W Press
Sep 14, 2001·Advances in Experimental Medicine and Biology·L C Burkly
May 30, 2002·Nature Reviews. Immunology·Flavius Martin, John F Kearney
Nov 13, 2002·Annual Review of Immunology·Fabienne MackayJeffrey Browning
Jan 9, 2003·European Journal of Immunology·Peter J MacardleHeddy Zola
Jan 31, 2003·Expert Opinion on Therapeutic Targets·Susan L KalledYen-Ming Hsu
Mar 26, 2003·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Yulia VugmeysterEleanor Canova-Davis
Jun 11, 2003·The Journal of Biological Chemistry·Marc PelletierYen-Ming Hsu
Jul 17, 2003·The Journal of Clinical Investigation·Danielle T AveryStuart G Tangye
Aug 30, 2003·International Immunopharmacology·Yulia VugmeysterEleanor Canova-Davis
Oct 11, 2003·Transplant Immunology·Carsten SchröderRichard N Pierson

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Citations

Jul 16, 2011·The Journal of Veterinary Medical Science·Akiko MoriyamaRyoji Yamaguchi
Nov 20, 2012·Bioanalysis·Ruth M Barnard
Mar 9, 2012·Journal of Neurovirology·Werner J D OuwendijkGeorges M G M Verjans
Apr 20, 2005·Journal of Immunotherapy·Yulia VugmeysterKathleen McKeever
Dec 16, 2017·Annals of Neurology·Ariele L Greenfield, Stephen L Hauser
Aug 2, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Romain MarlinElisabeth Menu
Dec 19, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ryuichi SugamataThomas L Leto
May 18, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·David PejoskiAnne-Sophie Beignon
Mar 5, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rama D Yammani, Karen M Haas

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