PMID: 8613489Nov 1, 1995Paper

B-cell superantigens: definition and potential impact on the immune response

Journal of Clinical Immunology
A I LevinsonL M Wheatley

Abstract

Superantigens have been extremely helpful tools in exploring fundamental questions in immunobiology including mechanisms of cell activation, tolerance, and autoimmunity. Until recently, attention has been focused exclusive on T-cell superantigens. However, new data suggest that there are superantigens that directly activate B cells. By definition, these agents (1) stimulate a high frequency of B cells, (2) target B cells that have restricted usage of VH or VL family genes, and (3) bind to immunoglobulins outside the sites that bind conventional antigens. A candidate B-cell superantigen that has received considerable attention in this laboratory is staphylococcal protein A. This agent is best known to the immunologist because of its ability to bind to the Fc fragment of IgG. This binding has been localized to two alpha-helical structures on each of four or five homologous regions that comprise the extracellular domain of protein A. However, it is now clear that protein A contains a second site that binds to determinants on the Fab regions of certain immunoglobulins independently of their heavy-chain isotype. In man this so-called alternative site appears to bind only to immunoglobulins that utilize heavy-chain genes of the VH3 s...Continue Reading

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Citations

Jan 24, 2006·Infection and Immunity·Amy L AndersonArnold I Levinson
Oct 9, 2003·Current Allergy and Asthma Reports·Claus BachertPaul Van Cauwenberge
Jan 18, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Amy L AndersonArnold I Levinson
Oct 19, 2011·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·William A McEwanLeo C James
Sep 24, 2016·The Journal of Allergy and Clinical Immunology·Jiun-Bo ChenHannah J Gould
Jan 10, 2002·Therapeutic Apheresis : Official Journal of the International Society for Apheresis and the Japanese Society for Apheresis·G MaticW Ramlow
Jun 23, 2009·Scandinavian Journal of Medicine & Science in Sports·M VeljkovicM Dopsaj
Jun 18, 1998·Annals of the New York Academy of Sciences·I Berczi
May 25, 2002·Allergy·C BachertP van Cauwenberge
May 17, 2011·Biochemistry. Biokhimii︠a︡·E V Sidorin, T F Solov'eva
May 28, 2019·Frontiers in Microbiology·Tarcisio BrignoliIsabel Delany
Jan 26, 2020·The European Respiratory Journal·Claus BachertBarbara M Bröker
Jul 27, 2021·Frontiers in Immunology·Chinh Tran-To SuSamuel Ken-En Gan

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