B-cell superantigens: implications for selection of the human antibody repertoire

Immunology Today
M Zouali

Abstract

For several decades, B-cell interactions with antigens were thought to occur only through a clonal activation mechanism, in which the hypervariable regions of the immunoglobulin receptor are exclusively involved in ligand binding. However, an additional mode of interaction can occur, whereby molecules, termed B-cell superantigens, can bind human B cells bearing immunoglobulin receptors of a given variable (V)-gene family. This mechanism requires contributions from regions outside the conventional hypervariable loops and results in a B-cell response of increased magnitude. Here, Moncef Zouali reviews recent in vitro and in vivo observations on human B-cell superantigens in the context of the current consensus of B-cell development, and discusses the implications of these novel concepts with respect to pathogenesis.

References

Jan 1, 1977·Annual Review of Biochemistry·A C WilsonT J White
Mar 1, 1976·European Journal of Immunology·A ForsgrenH Wigzell
Oct 1, 1992·The Journal of Clinical Investigation·W A MarascoJ Sodroski
Mar 20, 1992·Journal of Molecular Biology·J Foote, G Winter
Nov 15, 1990·Nature·G A BentleyR J Poljak
Jan 1, 1990·International Immunology·H W SchroederR M Perlmutter
Jun 1, 1990·The Journal of Experimental Medicine·J R TumangS M Friedman
Nov 16, 1990·Cell·C A Janeway
Jun 29, 1990·Science·P LenertM Zanetti
Sep 1, 1989·European Journal of Immunology·M ZoualiB D Stollar
Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·A Tutter, R Riblet
Aug 20, 1987·Journal of Molecular Biology·C Chothia, A M Lesk
Jul 1, 1995·The Journal of Clinical Investigation·G J SilvermanM Sasano
Oct 1, 1993·Scandinavian Journal of Immunology·S MüllerH Köhler
Dec 1, 1994·AIDS Research and Human Retroviruses·E M van der DonkR W van der Heijden
Jun 1, 1994·Nature Genetics·M Zouali
May 1, 1994·International Journal of Immunopharmacology·J P Bouvet
Jun 1, 1994·Human Molecular Genetics·I M TomlinsonG Winter
Jun 1, 1993·The Journal of Clinical Investigation·E H SassoE C Milner
Jul 1, 1993·The Journal of Experimental Medicine·J L HillsonE H Sasso
Mar 1, 1993·Microbiological Reviews·J A Levy
Apr 5, 1993·Journal of Molecular Biology·C F BarbasG R Pilkington
Jun 3, 1993·Nature·C Hamers-CastermanR Hamers
Sep 1, 1964·Biochemistry·S UTSUMI, F KARUSH
Oct 1, 1991·Current Biology : CB·V Pascual, J D Capra

❮ Previous
Next ❯

Citations

Oct 1, 1996·Arthritis and Rheumatism·D M Marcus
Apr 24, 1999·Applied Biochemistry and Biotechnology·L JuompanM Zouali
May 1, 1996·Molecular Immunology·M Ohlin, C A Borrebaeck
Jun 7, 2005·Cellular Immunology·Paul Hasler, Moncef Zouali
Apr 23, 2004·Life Sciences·Antonella D'AmbrosioFrancesca Quintieri
Jun 7, 2005·Molecular Immunology·Tania Romo-González, Enrique Vargas-Madrazo
Aug 12, 2003·Molecular Immunology·Mats Ohlin, Moncef Zouali
Aug 1, 1997·Immunology Today·G J Silverman
Oct 1, 1996·The Journal of Experimental Medicine·R PospisilR G Mage
Apr 1, 1997·The Journal of Clinical Investigation·S J FosterP E Lipsky
Aug 26, 1998·Clinical Chemistry and Laboratory Medicine : CCLM·D LauneC Granier
Mar 1, 2012·Molecular Medicine·Gwenoline BorhisMoncef Zouali
Feb 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·S Karray, M Zouali
Dec 3, 1999·British Journal of Haematology·O PritschG Dighiero
Jul 27, 2011·Immunogenetics·Katherine Jean Louise JacksonAndrew M Collins
Apr 15, 2004·Immunology Letters·Muriel ViauMoncef Zouali
Sep 23, 2008·Developmental and Comparative Immunology·J E ButlerI Kacskovics
Jan 1, 1997·International Reviews of Immunology·R Domiati-Saad, P E Lipsky
Jan 1, 1997·International Reviews of Immunology·J Townsley-FuchsL Goodglick
Jan 1, 1997·International Reviews of Immunology·P LenertM Zanetti
Jul 22, 2015·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Victoria MartinDeborah Dunn-Walters
Jul 5, 2005·Human Immunology·Tania Romo-GonzálezEnrique Vargas-Madrazo
Apr 15, 2005·Molecular Immunology·Tania Romo-González, Enrique Vargas-Madrazo
Mar 4, 2000·International Immunology·M N NeshatJ Braun
Mar 6, 2003·Genes and Immunity·P Hasler, M Zouali
Apr 25, 2019·International Journal of Molecular Sciences·Gilda VarricchiGianni Marone
Oct 27, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nancy P Y ChungJohn P Moore
Feb 6, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·John E ButlerKelly M Lager
Mar 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bing HeAndrea Cerutti

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antibody Repertoire Diversity

Antibody repertoire diversity and its role during natural infection is a prerequisite for molecular and structural elucidation of functionally protective immunity. Discover the latest insights into antibody diversity here.

B cell Differentiation

Depending on the signal received through the B cell receptor and other receptors, B cells differentiate into follicular or marginal zone B cells. Here is the latest research pertaining to this differentiation process.

Related Papers

Annals of the New York Academy of Sciences
G J SilvermanK Warnatz
Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
G J Fournié, P Druet
© 2021 Meta ULC. All rights reserved