PMID: 9186783Jan 1, 1997Paper

B cell superantigens: potential modifiers of the normal human B cell repertoire

International Reviews of Immunology
R Domiati-Saad, P E Lipsky

Abstract

Staphylococcal protein A (SPA), HIV gp120, and staphylococcal enterotoxins (SE) are B cell superantigens that induce VH specific B cell responses. In addition, the red blood cell antigens, i/I, have some features of a B cell superantigen. Binding of SPA, SE and HIV gp120 are VH family specific, whereas binding of i/I is VH gene specific. SPA and HIV gp120 function by stimulating VH3-expressing B cells, whereas SE appear to function by enhancing survival of the appropriate VH-expressing B cells. Moreover, HIV gp120 has been shown to delete VH3-expressing B cells. In this review, we describe evidence that shows how these superantigens may play a role in shaping the normal B cell repertoire.

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Feb 1, 2006·The Journal of Experimental Medicine·Makoto TsuijiHedda Wardemann
Oct 9, 2003·Current Allergy and Asthma Reports·Claus BachertPaul Van Cauwenberge
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