B-cell-T-cell activation and interaction in common variable immunodeficiency

Human Immunology
N RezaeiRobert C Read

Abstract

Common variable immunodeficiency (CVID) is a heterogeneous group of disorders, characterized by hypogammaglobulinemia and normal or low numbers of B cells, which predispose patients to recurrent infections. Peripheral blood mononuclear cells from 19 patients with CVID, and age- and sex-matched controls, were subjected to an in vitro assay of B-cell-T-cell activation and interaction, using anti-immunoglobulin (Ig)-D conjugated to dextran (alpha-delta-dex), as a polyclonal T independent type 2 antigen mimic, with and without anti-CD3/anti-CD28, as polyclonal T-cell stimuli. Stimulation of lymphocytes with either anti-CD3 or anti-CD3 plus anti-CD28 induced T-cell activation and proliferation in CVID patients who were similar to age- and sex-matched controls, but B cells of patients were significantly less activated when peripheral blood mononuclear cells were stimulated with polyclonal T-cell agonists alone. Comparison of CD86 expression in the patients with matched controls revealed that patients had low B-cell activation in response to T-cell stimuli (bystander T-cell help). In conclusion, this sample of CVID patients exhibits a defect of T-cell "help" to B cells, and/or B-cell response to T-cell help.

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Citations

Mar 14, 2014·BMC Immunology·Marie-Quitterie PicatJean-François Viallard
Sep 6, 2011·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Sander van AssenMarc Bijl
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Apr 9, 2016·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Laura Berrón-RuizLaura Bonifaz
Sep 17, 2016·Expert Review of Clinical Immunology·Gholamreza AziziAsghar Aghamohammadi
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Sep 17, 2014·Expert Review of Clinical Immunology·Asghar AghamohammadiNima Rezaei
Oct 30, 2010·Current Opinion in Allergy and Clinical Immunology

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