B-cell therapy in lupus nephritis: an overview

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Salem Almaani, Brad H Rovin

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune multisystem disease that commonly affects the kidneys. It is characterized by persistent autoantibody production that targets a multitude of self-antigens. B-cells, plasmablasts and plasma cells, as the source of these autoantibodies, play a major role in the development of lupus nephritis (LN), and are therefore promising therapeutic targets. To date, however, randomized clinical trials of B-cell therapies in LN have not lived up to expectations, whereas uncontrolled cohort and observational studies of B-cell antagonists have been more promising. In this article, we will review the current experience with B-cell therapy in LN and highlight the pitfalls that may have limited their success. We will conclude by suggesting B-cell-centric approaches to the management of LN based on what has been learned from the overall B-cell experience in SLE.

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Citations

Aug 16, 2018·Current Rheumatology Reports·Isabelle AyoubBrad H Rovin
Dec 5, 2019·International Journal of Molecular Sciences·Kongyang MaLiwei Lu
Jun 13, 2020·Journal of Nephrology·Claudio PonticelliGabriella Moroni
Feb 23, 2020·Frontiers in Immunology·Qian ZhangGuo-Min Deng
Jan 3, 2021·Kidney International·Ruifeng WangQi Cao
Jan 14, 2021·Neurology. Neuroimmunology and Neuroinflammation·Shinji AshidaTakayuki Kondo
Jun 22, 2021·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Alexander R Rosenkranz, Vladimir Tesar

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