B cells and the humoral response in melanoma: The overlooked players of the tumor microenvironment

Oncoimmunology
Giulia ChiaruttiniSophia N Karagiannis

Abstract

Evidence of tumor-resident mature B cell and antibody compartments and reports of associations with favorable prognosis in malignant melanoma suggest that humoral immunity could participate in antitumor defense. Likely striving to confer immunological protection while being subjected to tumor-promoting immune tolerance, B cells may engender multiple functions, including antigen processing and presentation, cytokine-mediated signaling, antibody class switching, expression and secretion. We review key evidence in support of multifaceted immunological mechanisms by which B cells may counter or contribute to malignant melanoma, and we discuss their potential translational implications. Dissecting the contributions of tumor-associated humoral responses can inform future treatment avenues.

References

Apr 11, 1985·Nature·A Lanzavecchia
Dec 5, 1995·Proceedings of the National Academy of Sciences of the United States of America·U SahinM Pfreundschuh
May 1, 1996·The Journal of Experimental Medicine·S L TopalianP F Robbins
Jun 18, 2002·Nature·Helen DaviesP Andrew Futreal
Jul 11, 2003·The New England Journal of Medicine·Minnie SarwalOscar Salvatierra
Mar 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Martin E DuddyAmit Bar-Or
Jun 19, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M AkliluT F Gajewski
Sep 2, 2004·Nature Medicine·Steven A RosenbergNicholas P Restifo
Oct 12, 2004·Cytokine·Sarah L Gaffen, Kathleen D Liu
Apr 13, 2005·The Journal of Experimental Medicine·Vincenzo BronteAntonella Viola
Apr 1, 2006·Cellular Immunology·Daniel Rodríguez-Pinto
Aug 4, 2006·Cancer Research·Satoshi InoueDorothy Scott
May 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Martin DuddyAmit Bar-Or
Jun 13, 2008·Kidney International·Valeriya ZarkhinMinnie M Sarwal
Aug 30, 2008·Molecular Cancer Therapeutics·John O RichardsJohn R Desjarlais
Aug 30, 2008·Blood·Tucker W LeBien, Thomas F Tedder
Feb 24, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Simon N WillisKevin C O'Connor
Jun 25, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Erica L CarpenterRobert H Vonderheide
Jul 22, 2009·Nature Biotechnology·Aran F LabrijnPaul W H I Parren
Feb 9, 2010·Cancer Cell·Pauline AndreuLisa M Coussens
Feb 17, 2010·The Journal of Experimental Medicine·Ying XiePaul Andrew Antony
Mar 3, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·David J DiLilloThomas F Tedder
Jun 8, 2010·The New England Journal of Medicine·F Stephen HodiWalter J Urba
Jun 15, 2011·Breast Cancer Research and Treatment·S M A MahmoudA R Green
Jun 22, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Qiao LiAlfred E Chang
Jul 23, 2011·Cancer Immunology, Immunotherapy : CII·Andrea LadányiJózsef Tímár
Aug 19, 2011·Neoplasia : an International Journal for Oncology Research·Alanna RuddellBrian M Iritani
Jan 25, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Peter A PrietoGiao Q Phan

❮ Previous
Next ❯

Citations

Dec 26, 2017·Frontiers in Immunology·Hassan SadozaiMirjam Schenk
Sep 19, 2017·Allergy·E Jensen-JarolimS N Karagiannis
Mar 9, 2018·Cancer Immunology, Immunotherapy : CII·Julia K WinklerJessica C Hassel
Feb 23, 2019·Journal for Immunotherapy of Cancer·Mirjam FässlerLukas Flatz
Jan 27, 2020·Journal of Cellular and Molecular Medicine·Ting-Feng XiongXiang Zhou
May 11, 2018·Journal of Oncology Practice·Jayadev Manikkam Umakanthan, Alissa Marr
May 6, 2020·The Journal of Experimental Medicine·Patricia M SantosLisa H Butterfield
Jan 17, 2020·Nature·Beth A HelminkJennifer A Wargo
Dec 14, 2017·International Journal of Molecular Sciences·Helena Kupcova SkalnikovaPetr Vodicka
Sep 5, 2018·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Jessica Da Gama DuarteJonathan M Blackburn
Jan 29, 2020·Nature Reviews. Immunology·George V SharonovDmitriy M Chudakov
Apr 10, 2018·Cellular & Molecular Immunology·Si-Si WangLi Zhang
Jan 9, 2018·The Journal of Clinical Investigation·Shannon M Liudahl, Lisa M Coussens
Feb 1, 2019·Pigment Cell & Melanoma Research·Kim R M BlenmanMarcus Bosenberg
Jan 10, 2020·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Ioannis PeppasMieke Van Hemelrijck
Jul 28, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Maartje C A Wouters, Brad H Nelson
Feb 12, 2021·Frontiers in Immunology·Zena N WillsmoreSophia N Karagiannis
Jul 4, 2021·Seminars in Immunology·Shabnam Shalapour, Michael Karin
Nov 17, 2021·Melanoma Research·Tara M DavidsonAnastasios Dimou

❮ Previous
Next ❯

Methods Mentioned

BETA
flow cytometry
transgenic
phage display
biopsy
dissection

Clinical Trials Mentioned

NCT01376713
NCT02142335

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.