B cells are not required for T cell priming in low zone tolerance to contact allergens and contact hypersensitivity

European Journal of Immunology
Wolfgang Seidel-GuyenotKerstin Steinbrink

Abstract

Low zone tolerance (LZT) to contact allergens is induced by epicutaneous exposure to haptens in subsensitizing doses resulting in an inhibition of contact hypersensitivity (CHS), which, in contrast, occurs after sensitization with immunogenic doses of allergens. Performing the protocol of tolerance induction resulted in robust LZT to allergens in B cell-deficient mice in vivo, indicating that B cells are not required for the induction and effector phase of LZT. However, CHS reactions in vivo were restricted in B cell-deficient mice as compared to wild-type (WT) mice. In contrast, analysis of hapten-specific T cell activation in vitro revealed a strong proliferative response of T cells derived from both WT and B cell-deficient sensitized mice. Similar to WT animals, T cells obtained from tolerized B cell-deficient mice produced a Tc2 cytokine pattern of LZT with high levels of IL-4 and IL-10, whereas sensitization of B cell-deficient mice resulted in the typical Tc1 cytokine profile of CHS. Adoptive transfer of CD8+ effector T cells from tolerized or sensitized B cell-deficient mice induced significant LZT or CHS reactions, respectively, in WT recipients, demonstrating that the development of hapten-specific effector CD8+ T cell...Continue Reading

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Citations

Sep 2, 2011·The Journal of Clinical Investigation·Ulrike LuckeyKerstin Steinbrink
Sep 1, 2012·The Journal of Allergy and Clinical Immunology·Ulrike LuckeyKerstin Steinbrink
Nov 30, 2012·The Journal of Investigative Dermatology·Anne GoubierDominique Kaiserlian
Oct 17, 2007·Contact Dermatitis·Jeppe Madura LarsenCharlotte Menné Bonefeld
Dec 21, 2010·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Helmut JonuleitUNKNOWN Working Group Dermatologic Research (Abeitsgemeinschaft Dermatologische Forschung, ADF)
Dec 14, 2011·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Anne Deen Christensen, Claus Haase
Jan 28, 2014·Contact Dermatitis·Charlotte Menné BonefeldJean-Pierre Lepoittevin
May 10, 2008·The American Journal of Pathology·M Ursula NormanPaul Kubes
May 6, 2006·The Journal of Allergy and Clinical Immunology·Wolfgang Seidel-GuyenotKerstin Steinbrink
May 21, 2014·PloS One·Edmund A RossiDavid M Goldenberg
Jul 28, 2007·Journal of Leukocyte Biology·Hossam M Ashour, Tarek M Seif
Aug 12, 2018·Archives of Toxicology·Emanuela CorsiniAristidis M Tsatsakis
Jan 16, 2019·Nature Communications·Avijit RayBonnie N Dittel

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