B cells from CBA/N mice do not proliferate following ligation of CD40

European Journal of Immunology
J Hasbold, G G Klaus

Abstract

The CBA/N mouse carries the X-linked immunodeficiency xid, resulting in defective B cell development. B cells from these animals cannot mount antibody responses to type 2 T-independent antigens, and do not synthesize DNA when stimulated with anti-immunoglobulin (Ig) antibodies which are mitogenic for normal B cells. The primary antibody responses of CBA/N mice to T-dependent antigens have also been reported to be abnormal. Here we describe the results of experiments which demonstrate that the B cells from these animals respond abnormally to ligation of CD40, a B cell surface molecule now known to play a key role during T cell-B cell interactions, via its interaction with the counterligand (CD40L) expressed by activated T cells. Hence, xid B cells fail to proliferate when cultured with preactivated T helper type 2 (Th2)T cells (known to express CD40L), with a soluble CD40L-CD8 fusion protein, or in response to monoclonal antibodies to CD40, even in the presence of IL-4 and/or anti-Ig reagents. However, xid B cells do receive abortive activation signals following ligation of CD40, as manifested by up-regulation of class II major histocompatibility complex and CD23 antigens. Since the xid defect has now been identified as a point ...Continue Reading

References

May 7, 1992·Nature·R J ArmitageC R Maliszewski
Jun 1, 1992·Current Opinion in Immunology·R Noelle, E C Snow
Nov 1, 1989·European Journal of Immunology·K P RigleyG G Klaus
Aug 1, 1984·European Journal of Immunology·M H JuliusK U Hartmann
Feb 1, 1980·The Journal of Experimental Medicine·E S MetcalfN R Klinman

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Citations

Aug 1, 1996·Current Opinion in Immunology·A B Satterthwaite, O N Witte
Aug 1, 1997·Current Opinion in Immunology·S Desiderio
Apr 11, 1995·Proceedings of the National Academy of Sciences of the United States of America·H H WortisD C Parker
Oct 1, 1996·Proceedings of the National Academy of Sciences of the United States of America·J S AndersonH H Wortis
Aug 28, 1999·International Immunology·K HorikawaT Yamamoto
Jan 1, 1996·Annual Review of Immunology·A Satterthwaite, O Witte
Jan 1, 1997·Annual Review of Immunology·J B Bolen, J S Brugge
Oct 1, 1994·The Journal of Clinical Investigation·M E ConleyD Campana
Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·S NisitaniM I Wahl
Dec 1, 1996·The Journal of Allergy and Clinical Immunology·M MayumiK Katamura
Sep 1, 1995·Immunity·W N KhanL A Herzenberg
Sep 1, 1995·Immunity·J D KernerR M Perlmutter
Jun 17, 1999·Clinical Immunology : the Official Journal of the Clinical Immunology Society·D J Rawlings
Feb 26, 2014·Molecular and Cellular Biology·Justin M DrakeOwen N Witte
Jan 1, 1995·Springer Seminars in Immunopathology·H C MorseJ W Hartley
Oct 11, 1996·The Journal of Biological Chemistry·S C BunnellL J Berg
Jan 1, 1997·International Reviews of Immunology·G G KlausJ Cliff
Mar 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Joseph R TumangThomas L Rothstein
Oct 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shannon K O'NeillAlison Finnegan
Jan 9, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Joanne M LumsdenRichard J Hodes
Nov 21, 2007·Clinical and Experimental Dermatology·N TalsaniaS D Orpin
Aug 9, 1996·Science·M LeitgesA Tarakhovsky

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