B cells in systemic autoimmune disease: recent insights from Fas-deficient mice and men

Current Opinion in Immunology
K B Elkon, A Marshak-Rothstein

Abstract

In mice functionally deficient for either Fas or Fas ligand expression, the failure of Fas-ligand-expressing cytotoxic T cells to eliminate autoreactive B cells can result in excessive autoantibody production. Recent in vitro studies have shown that B cells activated by CD40 ligand become extremely sensitive to Fas-mediated apoptosis while IL-4 and/or surface IgM receptor engagement protects B cells from Fas ligand cytolysis. Potential in vivo sites for Fas ligand regulation of self-reactive B cells have been suggested and implications for human disease have been investigated.

References

May 1, 1988·The Journal of Experimental Medicine·T J SantoroB L Kotzin
Jun 1, 1967·The Journal of Pediatrics·V C Canale, C H Smith
Nov 21, 1995·Proceedings of the National Academy of Sciences of the United States of America·D AshanyK B Elkon
Nov 1, 1995·European Journal of Immunology·L MandikJ Erikson
Mar 1, 1994·The Journal of Clinical Investigation·E MyslerK B Elkon
Oct 1, 1994·Clinical Immunology and Immunopathology·S OhsakoS Kashiwazaki
Nov 1, 1994·European Journal of Immunology·B C RichardsonR M Marks
Feb 1, 1995·The Journal of Experimental Medicine·M A MaldonadoB L Kotzin
Mar 1, 1995·The Journal of Experimental Medicine·J H RoarkJ Erikson
Oct 1, 1995·European Journal of Immunology·K B OnelK B Elkon
Sep 1, 1995·European Journal of Immunology·D R KohT W Mak
Nov 1, 1995·The Journal of Experimental Medicine·P GarroneJ Banchereau
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·M AdachiS Nagata
Jun 1, 1995·The Journal of Experimental Medicine·R CarsettiM C Lamers
Jan 19, 1995·Nature·C ChenM Weigert
Apr 1, 1994·The Journal of Experimental Medicine·A M JevnikarL H Glimcher
May 1, 1993·The Journal of Experimental Medicine·C MohanS K Datta
Dec 5, 1995·Proceedings of the National Academy of Sciences of the United States of America·K G SmithD M Tarlinton
Jan 1, 1996·European Journal of Immunology·J WangT Watanabe
Mar 19, 1996·Proceedings of the National Academy of Sciences of the United States of America·C C Goodnow
May 28, 1996·Proceedings of the National Academy of Sciences of the United States of America·R P Junghans, C L Anderson
Mar 5, 1996·Proceedings of the National Academy of Sciences of the United States of America·S K RayB Diamond
Jun 1, 1996·Current Opinion in Immunology·L Van Parijs, A K Abbas
Dec 1, 1995·Arthritis and Rheumatism·N GoelM F Seldin

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Citations

Mar 4, 1998·European Journal of Immunology·I JeremiasK M Debatin
Jan 20, 1998·Arthritis and Rheumatism·K NishiokaT Kobata
Dec 4, 1998·Springer Seminars in Immunopathology·T HasunumaK Nishioka
Feb 17, 2000·Journal of Immunological Methods·N TakahashiY Nishi
Jul 14, 2001·Molecular Immunology·M Boes
Jun 17, 2000·Trends in Neurosciences·J J Archelos, H P Hartung
Feb 18, 1999·Toxicology Letters·M PallardyH Lebrec
Apr 27, 2000·Current Opinion in Immunology·K A Sabelko-Downes, J H Russell
Mar 20, 2002·The British Journal of Dermatology·G De Panfilis
Sep 13, 2002·Immunology and Cell Biology·Erika CretneyMark J Smyth
May 23, 1998·Annual Review of Immunology·T J Vyse, B L Kotzin
May 3, 2001·Cellular Immunology·A Kretz-Rommel, R L Rubin
Feb 3, 2000·Proceedings of the National Academy of Sciences of the United States of America·M BoesJ Chen
Feb 27, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Mieko ToyodaStanley C Jordan
Jul 28, 2011·Human Mutation·Jianming WuRobert P Kimberly
Jun 26, 1998·The Journal of Dermatology·M FushimiM Takigawa
Feb 9, 2000·Rheumatology·M L Stoll, J Gavalchin
Apr 24, 2001·The American Journal of Gastroenterology·A J Czaja
Feb 15, 2000·International Reviews of Immunology·C T RavirajanD A Isenberg
Nov 19, 1997·Arthritis and Rheumatism·A K VaishnawK B Elkon
Feb 5, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·F BatteuxG Chiocchia
Oct 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·K D Klonowski, M Monestier

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