B cells in the formation of tertiary lymphoid organs in autoimmunity, transplantation and tumorigenesis.

Current Opinion in Immunology
Elisa CorsieroCostantino Pitzalis

Abstract

Tertiary lymphoid organs named also tertiary lymphoid structures (TLS) often occur at sites of autoimmune inflammation, organ transplantation and cancer. Although the mechanisms for their formation/function are not entirely understood, it is known that TLS can display features of active germinal centres supporting the proliferation and differentiation of (auto)-reactive B cells. In this Review, we discuss current knowledge on TLS-associated B cells with particular reference on how within diseased tissues these structures are linked to either deleterious or protective outcomes in patients and the potential for therapeutic targeting of TLS through novel drugs.

Citations

Feb 11, 2020·Transplantation·Edward J Filippone, John L Farber
Jan 11, 2020·Frontiers in Immunology·Shanshan LuoDesheng Hu
Aug 29, 2020·Annual Review of Pharmacology and Toxicology·K Michael PollardDwight H Kono
Jan 26, 2020·The Journal of Investigative Dermatology·Hisashi Nomura, Masayuki Amagai
Jan 6, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Catarina Gago da GraçaReina E Mebius
Jun 1, 2021·Frontiers in Immunology·Marta Trüb, Alfred Zippelius
Jun 1, 2021·Frontiers in Immunology·Jessica N FildermanWalter J Storkus
Aug 3, 2021·Frontiers in Immunology·Mélanie DieudéMarie-Josée Hébert
Jul 14, 2021·Immunological Reviews·Amy P RossiE Steve Woodle
Jul 13, 2021·Cellular and Molecular Gastroenterology and Hepatology·Francesca R DelvecchioHemant M Kocher
Jul 11, 2021·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Yuki SatoMotoko Yanagita
Sep 14, 2021·Frontiers in Immunology·Jacqueline A WrightWasif N Khan

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