B-Cells induce regulatory T cells through TGF-β/IDO production in A CTLA-4 dependent manner

Journal of Autoimmunity
A NouëlS Hillion

Abstract

A number of studies have suggested that B cell mediated-regulation contributes to the establishment of immunological tolerance. However, the precise mechanisms by which regulatory B cells establish and maintain tolerance in humans remain to be determined. The objective of the current study is to understand the cellular and molecular bases of B-cell regulatory functions in humans. To describe the mechanisms regulating the functional plasticity of regulatory B cells, we used an in vitro co-culture model based on autologous mixed lymphocyte cultures involving freshly isolated B and T cells. The results show that activated B cells regulate T cell proliferation through producing transforming growth factor (TGF)-β and indoleamine 2,3-dioxygenase (IDO). The production of TGF-β and IDO leads to the induction of not only "natural" regulatory T cells but also of TGF-β-producing CD4(+) T cells and IL-10-producing regulatory T cells. Furthermore, we evidenced for the first time that CTLA-4 induces B-cells to produce IDO and to become effective induced regulatory B cells (iBregs). This study emphasizes a novel regulatory axis and open news insights in how to manage regulatory B cell functions in autoimmunity.

References

Mar 21, 1998·The Journal of Experimental Medicine·F LühderD Mathis
Dec 18, 1998·Science·K M LeeJ A Bluestone
Sep 24, 2002·Nature Immunology·Simon FillatreauStephen M Anderton
Oct 9, 2002·Nature Immunology·Ursula GrohmannPaolo Puccetti
May 10, 2003·Trends in Immunology·Ursula GrohmannPaolo Puccetti
Oct 28, 2003·Nature Immunology·Francesca FallarinoPaolo Puccetti
Oct 2, 2004·Nature Reviews. Immunology·Andrew L Mellor, David H Munn
Aug 6, 2005·Autoimmunity Reviews·Ruth Y LanM Eric Gershwin
Mar 28, 2008·Immunological Reviews·Jessica B KatzGeorge C Prendergast
Sep 20, 2008·Blood·Theresa TretterHanns-Martin Lorenz
Jul 1, 2009·Arthritis and Rheumatism·Pierre YouinouYves Renaudineau
Dec 2, 2009·European Journal of Immunology·Elizabeth C JuryMichael R Ehrenstein
Mar 13, 2010·Nature Reviews. Immunology·Frances E Lund, Troy D Randall
Mar 23, 2010·The Journal of Allergy and Clinical Immunology·Sylvie AmuPadraic G Fallon
May 26, 2010·Proceedings of the National Academy of Sciences of the United States of America·Burles A JohnsonAndrew L Mellor
Feb 15, 2011·Journal of Autoimmunity·Sébastien LemoineChristophe Jamin
Aug 2, 2011·Nature Immunology·Maria T PallottaUrsula Grohmann
Oct 18, 2011·Autoimmunity Reviews·Christopher J LessardKathy L Moser
May 26, 2012·Nature Reviews. Immunology·Kathryn J WoodJoanna Hester
Oct 30, 2012·Trends in Immunology·David H Munn, Andrew L Mellor

❮ Previous
Next ❯

Citations

Aug 21, 2015·Expert Review of Clinical Immunology·Madeline FryerGerald Brandacher
Jun 14, 2015·International Immunology·Claudia Mauri, Madhvi Menon
Jun 18, 2015·Frontiers in Immunology·Marian Nassef Kadry Naguib RoufaielRaymond J Steptoe
Jun 13, 2016·Journal of Autoimmunity·Lai Fong KokScott N Byrne
Jun 15, 2016·Thyroid : Official Journal of the American Thyroid Association·Rajni SharmaPatrizio Caturegli
Jun 28, 2016·Clinical Reviews in Allergy & Immunology·Laurent SimoninYves Renaudineau
Jul 15, 2016·Nature Reviews. Rheumatology·Alain SarauxValérie Devauchelle-Pensec
Jul 17, 2016·Clinical Reviews in Allergy & Immunology·Carlo Selmi
Jun 1, 2016·La Presse médicale·Jacques-Olivier Pers, Alain Saraux
Jan 21, 2017·Journal of Neuroinflammation·Nicolas MolnarfiPatrice H Lalive
Feb 17, 2018·Cancer Immunology, Immunotherapy : CII·Shimrit Ringelstein-HarlevTami Katz
Mar 2, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J S YoungA S Chong
Jul 26, 2018·Current Opinion in Organ Transplantation·Kanishka MohibDavid M Rothstein
Sep 29, 2019·Immunological Reviews·Rowa Y AlhabbabGiovanna Lombardi
Jul 30, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Kanishka MohibDavid M Rothstein
Jun 23, 2016·Oncotarget·Meng ShenXiubao Ren
Jul 18, 2015·Clinical Science·Amanda W S YeungShane R Thomas
Dec 14, 2016·Mediators of Inflammation·Laura Carreras-PlanellaMarcella Franquesa
Feb 7, 2019·Oncoimmunology·Audrey MohrChristophe Jamin
Jan 7, 2020·Cancer Immunology, Immunotherapy : CII·Akshay J PatelGary W Middleton
Mar 2, 2017·The Journal of Clinical Investigation·Claudia Mauri, Madhvi Menon
Jul 22, 2018·International Journal of Molecular Sciences·Ana Esteve-SoléLaia Alsina
May 10, 2017·Archivum Immunologiae Et Therapiae Experimentalis·Katarzyna BocianNadzieja Drela
Dec 15, 2018·Journal of Leukocyte Biology·Jinfeng LiGuiwen Feng
Nov 18, 2018·Nature Reviews. Nephrology·Kristine OleinikaAlan D Salama
Mar 24, 2016·Journal of Clinical Immunology·Achilleas FloudasPadraic G Fallon
Jan 8, 2021·Immunological Reviews·Madhvi MenonHalima Ali Shuwa
Aug 28, 2019·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Gerwyn MorrisMichael Maes
Jan 24, 2021·Immunological Reviews·Aravind CherukuriDavid M Rothstein
Jan 21, 2021·Journal of Inflammation Research·Endeshaw Chekol AbebeZelalem Tilahun Muche
Mar 23, 2021·Nature Communications·Md Mahmudul HasanSangKon Oh
Apr 4, 2021·International Immunopharmacology·Yuanming JingLin Zhang
Apr 6, 2021·Clinical & Translational Immunology·Guoli HuaiCharles Gerard Rickert
Apr 17, 2021·International Immunopharmacology·Huan-Rong LanXue Yang
May 4, 2021·Frontiers in Immunology·Qiugang ZhuJie Tian
May 18, 2021·Frontiers in Immunology·Diego CatalánOctavio Aravena

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Lymphoproliferative Syndrome

Autoimmune lymphoproliferative syndrome (ALPS) is a rare genetic disorder of abnormal lymphocyte survival caused by defective Fas mediated apoptosis. Discover the latest research on ALPS here.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.