B cells inhibit the antitumor immunity against an established murine fibrosarcoma

Oncology Letters
Andrea MagliocoGraciela I Dran

Abstract

Despite the classic role of B cells in favoring the immune response, an inhibitory action of B lymphocytes in tumor immunity has emerged in certain studies. In methylcolanthrene-induced murine fibrosarcoma (MCC), the loss of immunogenicity and the establishment of tolerance are paralleled by systemic immune suppression and the appearance of B(+)IL-10(+) cells in tumor-draining lymph nodes. The present study aimed to assess the role of the B(+)IL-10(+) cell population in the immune evasion and tolerance induced by MCC through the depletion of B cells in mice at various times of tumor progression: Prior to or subsequent to tumor implantation. Tumor growth and immunological parameters were evaluated. B cell depletion prior to tumor inoculum enhanced tumor growth, initiating the onset of the tumor-induced systemic immune response; however, an increase in the T regulatory cells (Tregs) at the tumor-draining lymph node could account for tumor exacerbation. B cell depletion once the tumor was established resulted in decreased tumor growth and a delayed onset of tolerance. Additionally, B cell absence exacerbated T cell dependent-tumor rejection, reduced Tregs and increased cytotoxic CD8(+) T cells. In vitro analysis showed a direct ef...Continue Reading

References

Dec 15, 1991·Journal of Immunological Methods·P Matzinger
May 19, 1998·Nature Medicine·Z QinT Blankenstein
Mar 13, 2001·Annual Review of Immunology·K W MooreA O'Garra
Feb 20, 2003·The Journal of Experimental Medicine·Claudia MauriMarco Londei
Jun 10, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Vrajesh V ParekhGyan C Mishra
Apr 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Song Guo ZhengDavid A Horwitz
May 25, 2005·International Journal of Cancer. Journal International Du Cancer·Sangeeta ShahJoseph D Rosenblatt
Jul 30, 2005·Oncology Research·Oscar D BustuoabadRoberto P Meiss
Mar 7, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alison CrawfordDavid Gray
Mar 25, 2006·Nature Reviews. Immunology·Weiping Zou
Aug 4, 2006·Cancer Research·Satoshi InoueDorothy Scott
Dec 1, 2006·Annual Review of Immunology·Gabriel A RabinovichEduardo M Sotomayor
Oct 27, 2007·Cancer Immunology, Immunotherapy : CII·Paula ChiarellaRaúl A Ruggiero
Apr 26, 2008·Nature Reviews. Immunology·Simon FillatreauStephen M Anderton
Aug 30, 2008·Blood·Tucker W LeBien, Thomas F Tedder
Sep 2, 2008·Immunological Reviews·Jean-David BouazizThomas F Tedder
Mar 6, 2009·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Steven K Lundy
Feb 12, 2010·Annals of the New York Academy of Sciences·David J DiLilloThomas F Tedder
Mar 3, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·David J DiLilloThomas F Tedder
Apr 7, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rei WatanabeManabu Fujimoto
Apr 27, 2010·Expert Opinion on Biological Therapy·Theresa L Whiteside
Jan 27, 2011·Cancer Immunology, Immunotherapy : CII·Federica CavalloPier-Luigi Lollini
May 18, 2012·Science Translational Medicine·Andrew J RechRobert H Vonderheide
Jul 10, 2012·Cancer Immunology, Immunotherapy : CII·Yu ZhangJoseph D Rosenblatt
Feb 7, 2013·Cancer Research·Stefanie LindnerBernd Jahrsdörfer

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