B-chromosome origin in the endemic New Zealand frog Leiopelma hochstetteri through sex chromosome devolution

Genome Génome / Conseil National De Recherches Canada
T F SharbelA Houben

Abstract

The endemic New Zealand frog Leiopelma hochstetteri has variable numbers of mitotically stable B chromosomes. To assess whether the B chromosomes were derived from the autosome complement, they were isolated by micromanipulation and their DNA amplified by degenerate oligonucleotide primed PCR. Southern hybridizations of B chromosome DNA probes to genomic DNA from males and females characterized by differing numbers of B chromosomes demonstrated that the B chromosomes were derived from the univalent W sex chromosome characteristic of North Island populations. The presence of homologous B chromosome specific sequences from geographically distinct populations indicates a single origin of the B chromosomes. Furthermore, a primitive homology shared by B chromosomes and the W sex chromosome from an ancestral WZ/ZZ karyotype, which is still present in frogs from Great Barrier Island, shows that the B chromosomes originated soon after the univalent W sex chromosome had originated. Sequence analysis revealed that B chromosome DNA is composed of repeat sequences and has the potential to form stable hairpin structures. The molecular dynamics of these structures may reflect an inherent propensity to undergo rapid change in nucleotide seque...Continue Reading

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Citations

Mar 21, 2000·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J P CamachoL W Beukeboom
Jul 26, 2017·The New Phytologist·Ugo D'AmbrosioSònia Garcia
Dec 24, 2008·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·María TeruelJuan Pedro M Camacho
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Mar 25, 2011·Sexual Development : Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation·J P M CamachoJ Cabrero
Sep 26, 2007·Genome Génome / Conseil National De Recherches Canada·Sylvia MarschnerAndreas Houben
Sep 17, 2014·PloS One·José Carlos Pansonato-AlvesFausto Foresti

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