B lymphocyte activation by coinfection prevents immune control of friend virus infection.

The Journal of Immunology : Official Journal of the American Association of Immunologists
Rute MarquesGeorge Kassiotis

Abstract

Although the adaptive immune response almost invariably fails to completely eliminate retroviral infections, it can exert significant protection from disease and long-term control of viral replication. Friend virus (FV), a mouse retrovirus, causes persistent infection in all strains of mice and erythroleukaemia in susceptible strains, the course of which can be strongly influenced by both genetic and extrinsic factors. In this study we examine the impact of coinfection on the requirements for immune control of FV infection. We show that congenic C57BL/6 mice, in which the introduction of an allele of the Friend virus susceptibility 2 gene provides the potential for FV-induced leukemia development, effectively resist FV infection, and both T cell- and Ab-dependent mechanisms contribute to their resistance. However, we further demonstrate that coinfection with lactate dehydrogenase-elevating virus (LDV) renders these otherwise immunocompetent mice highly susceptible to FV infection and subsequent disease. The presence of LDV delays induction of FV-specific neutralizing Abs and counteracts the protective contribution of adaptive immunity. Importantly, the disease-enhancing effect of LDV coinfection requires the presence of a polyc...Continue Reading

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Citations

Jul 9, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Georgina ThorbornGeorge Kassiotis
May 30, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sam X LiMario L Santiago
Sep 21, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bettina MavrommatisGeorge Kassiotis
Aug 16, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mickaël J-Y PloquinGeorge Kassiotis
Dec 30, 2014·Retrovirology·Kathrin GibbertUlf Dittmer
Sep 11, 2012·Immunologic Research·Kalani HalemanoMario L Santiago
Jul 21, 2012·Bulletin of Experimental Biology and Medicine·O T KudaevaV A Kozlov
Jan 6, 2016·Nature Communications·Julia MerkenschlagerGeorge Kassiotis
Mar 28, 2017·The Journal of Experimental Medicine·Andrew GetahunJohn C Cambier
Jun 29, 2018·Frontiers in Immunology·Luca DanelliGeorge Kassiotis
Dec 25, 2010·Acta Microbiologica Et Immunologica Hungarica·Joseph G Sinkovics
Jul 24, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Amanda K DuleyGeorge Kassiotis
Jun 23, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mario L SantiagoWarner C Greene

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