PMID: 2492949Feb 1, 1989Paper

B lymphocyte function in multiple myeloma: analysis of T cell- and monocyte-dependent antibody production

European Journal of Haematology
J PetersenE Dickmeiss

Abstract

T-cell and B-cell functions were studied in 35 patients with untreated multiple myeloma (MM) and in 16 patients with MM treated with prednisolone, melphalan and vincristine. The numbers of CD4+ T cells were normal in untreated MM patients, but markedly decreased in treated patients, whereas CD8+ cell numbers were normal in untreated and treated patients. Mitogen-induced as well as antigen-induced lymphocyte proliferative responses were reduced, but not further affected by treatment. The antigen-induced proliferative responses by lymphocytes of treated, but not of untreated patients, correlated positively to the proportions of CD4+ cells among MNC. Taken together, the findings suggest selective loss of CD4+ subpopulations during cytotoxic treatment. Pokeweed mitogen (PWM)-induced Ig production was generally low, but significantly reduced Ig production was only seen in experiments employing MM B cells and monocytes co-cultured with irradiated T-enriched cells. Irradiated MM T cells displayed normal helper function when co-cultured with normal B cells stimulated with PWM. MM B cells and monocytes cultured with irradiated normal T cells produced little Ig; however, MM monocytes were not suppressive. In 2 of 3 patients with either I...Continue Reading

References

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Citations

Jan 1, 1993·Cancer Immunology, Immunotherapy : CII·H Everaus, J Lehtmaa
Nov 1, 1993·Leukemia & Lymphoma·H EverausK Zilmer
Mar 21, 1998·British Journal of Haematology·M A FrassanitoF Dammacco

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