PMID: 9525643Apr 3, 1998Paper

B-lymphocyte proliferation during bovine leukemia virus-induced persistent lymphocytosis is enhanced by T-lymphocyte-derived interleukin-2

Journal of Virology
E S TruebloodT F McElwain

Abstract

Bovine leukemia virus (BLV)-induced persistent lymphocytosis is characterized by a polyclonal expansion of CD5+ B lymphocytes. To examine the role of the cytokine microenvironment in this virus-induced B-lymphocyte expansion, the expression of interleukin-2 (IL-2), IL-4, IL-10, and gamma interferon (IFN-gamma) mRNA, was measured in stimulated peripheral blood mononuclear cells from persistently lymphocytotic BLV-infected cows, nonlymphocytotic BLV-infected cows, and uninfected cows. IL-2 and IL-10 mRNA expression and IL-2 functional activity were significantly increased when peripheral blood mononuclear cells from persistently lymphocytotic cows were stimulated with concanavalin A (ConA). Additionally, during persistent lymphocytosis, peak IL-2 and IL-10 mRNA expression was delayed, and elevated expression was prolonged. To determine the potential biologic importance of increased IL-2 and IL-10 expression, the response of isolated B lymphocytes from persistently lymphocytotic cows to human recombinant cytokines and to cytokine-containing supernatants from isolated T lymphocytes was examined. While recombinant human IL-10 (rhIL-10) did not consistently induce detectable changes, rhIL-2 increased viral protein (p24) and IL-2 rece...Continue Reading

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Citations

Aug 16, 2001·The Journal of Veterinary Medical Science·H KabeyaM Onuma
Dec 4, 2003·Journal of Virology·Christophe DebacqLuc Willems
Jun 24, 1999·The Journal of Veterinary Medical Science·H KabeyaM Onuma
Sep 21, 2002·Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health·J BeyerM Ziller
Nov 17, 2001·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Y ZhangW C Brown
Feb 20, 2003·Journal of Hematotherapy & Stem Cell Research·J ChenD E Harrison
Jun 22, 2013·Journal of the American Veterinary Medical Association·Cheryl L SwensonPaul C Bartlett
Aug 11, 2001·Veterinary Immunology and Immunopathology·H KabeyaM Onuma
Jan 3, 2015·Veterinary Immunology and Immunopathology·Meredith C Frie, Paul M Coussens
Jul 6, 2021·Frontiers in Veterinary Science·Ewerton de Souza LimaFernando Nogueira de Souza

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