PMID: 6975477Aug 1, 1981Paper

B-lymphocyte responses to trinitrophenyl-conjugated Ficoll: requirement for T lymphocytes and Ia-bearing adherent cells

Proceedings of the National Academy of Sciences of the United States of America
N L LetvinR N Germain

Abstract

These studies were done to characterize the cellular requirements for B-lymphocyte responses to the haptenated polysaccharide trinitrophenyl-conjugated Ficoll. By using an in vitro microculture system, it was demonstrated that hapten-specific anti-trinitrophenyl-conjugated Ficoll plaque-forming cell responses by B lymphocytes require Ia-bearing adherent accessory cells and Thy 1+ Lyt 1+2- nylon wool-nonadherent (T) lymphocytes. Such T cells could be primed in vivo with nonderivatized Ficoll to show carrier-specific helper cell function for derivatized Ficoll responses in vitro. The implications of these findings for our understanding of b-lymphocyte triggering by so-called T-independent antigens are discussed.

References

Dec 7, 1973·Nature·M C Raff
Oct 1, 1973·European Journal of Immunology·M H JuliusL A Herzenberg
May 1, 1974·The Journal of Experimental Medicine·D E MosierP R McMaster
May 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·N L LetvinR N Germain

❮ Previous
Next ❯

Citations

Sep 23, 1982·The New England Journal of Medicine·M M EiblC C Zielinski
Dec 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·S MoriwakiS Tonegawa
Feb 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·E ZismanE Mozes
Apr 1, 1982·The Journal of Experimental Medicine·M E ShapiroR W Finberg
Nov 1, 1985·The Journal of Experimental Medicine·L H ShapiroJ E Neiderhuber
Jan 1, 1993·Immunopharmacology and Immunotoxicology·S R SmithM I Siegel
Feb 1, 1985·Cellular Immunology·M J Caulfield
Jan 1, 1982·Immunological Reviews·Y J Rosenberg
Jan 1, 1982·Immunological Reviews·B Subbarao, D E Mosier
Aug 1, 1984·Immunological Reviews·B R Bloom, V Mehra
Oct 1, 1983·Scandinavian Journal of Immunology·C Fernandez, E Severinson
Oct 1, 1982·Scandinavian Journal of Immunology·C WoodG Möller
Feb 24, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·John B CareyFrank N van Pelt
Dec 1, 1988·The New England Journal of Medicine·R J DattwylerM G Golightly
Dec 10, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·John E ButlerDavid Francis
Mar 1, 1986·Immunological Investigations·P J Kaplan, J S Garvey
Aug 1, 1990·European Journal of Immunology·G T ReheJ J Mond

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.