B-lymphocyte subpopulations in patients with selective IgA deficiency.

Journal of Clinical Immunology
Jana NechvatalovaJirí Litzman

Abstract

Selective deficiency IgA (IgAD) is the most common primary abnormality of immunoglobulin production with unknown pathophysiology. It is genetically related to common variable immunodeficiency (CVID), where besides IgA also IgG and frequently IgM serum levels are decreased. In this study we focused on determination of B-lymphocyte developmental stages and searching for similarities between CVID and IgAD. Using flow cytometry we determined major lymphocyte subpopulations and B-lymphocyte subsets: naïve (CD27(-)IgD(+)), marginal zone cells (CD27(+)IgD(+)), class-switched memory cells (CD27(+)IgD(-)), "double-negative" B cells (CD27(-)IgD(-)), transitional cells (IgM(++)CD38(++)), plasmablasts (CD38(+++)IgM(+) or IgM(-)), and CD21(low)CD38(low) cells in 80 patients with IgAD, 48 patients with CVID, and 80 control persons. Compared to healthy controls, a decrease in the absolute number and frequency of CD4+ cells (both < 0.001) was observed in IgAD patients. A decrease in the frequency of switched memory cells (P < 0.001), transitional cells (P = 0.035) as well as plasmablasts (P < 0.001) and an increase in the CD21(low)CD38(low) subset (P = 0.007) was observed in IgAD patients compared to control persons. No significant differences...Continue Reading

References

Nov 1, 1995·Clinical Immunology and Immunopathology·I VorechovskýL Hammarström
Sep 1, 1996·Clinical Immunology and Immunopathology·T EspañolJ M Bertran
Jul 22, 1999·Clinical Immunology : the Official Journal of the Clinical Immunology Society·C Cunningham-Rundles, C Bodian
Dec 22, 1999·Clinical Immunology : the Official Journal of the Clinical Immunology Society·M E ConleyA Etzioni
Sep 29, 2000·European Journal of Immunology·J C BrouetB Royer
Nov 4, 2000·International Archives of Allergy and Immunology·J LitzmanJ Lokaj
Sep 29, 2004·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Claudia WehrKlaus Warnatz
Jun 1, 2005·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Jimmy KoCharlotte Cunningham-Rundles
Jun 1, 2006·Clinical and Experimental Immunology·L HummelshojL K Poulsen
Sep 12, 2006·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Daniele MorattoRaffaele Badolato
May 17, 2008·Nature Reviews. Immunology·Andrea Cerutti
Jun 4, 2008·International Archives of Allergy and Immunology·Asghar AghamohammadiLennart Hammarstrom
Jun 19, 2008·Cytometry. Part B, Clinical Cytometry·Klaus Warnatz, Michael Schlesier
Jul 22, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Danielle T AveryStuart G Tangye
Aug 30, 2008·Blood·Tucker W LeBien, Thomas F Tedder
Apr 7, 2009·British Journal of Haematology·Helen Chapel, Charlotte Cunningham-Rundles
Aug 12, 2009·Proceedings of the National Academy of Sciences of the United States of America·Mirzokhid RakhmanovKlaus Warnatz
Apr 2, 2010·International Archives of Allergy and Immunology·Jiri LitzmanJindrich Lokaj
Aug 13, 2011·International Archives of Allergy and Immunology·Asghar AghamohammadiNima Rezaei

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Citations

Sep 24, 2014·Journal of Clinical Immunology·Zdenek HelJiri Litzman
Jan 23, 2016·Molecular Immunology·Reza YazdaniAsghar Aghamohammadi
Aug 27, 2015·Expert Review of Clinical Immunology·Reza YazdaniAsghar Aghamohammadi
Jun 9, 2016·Expert Review of Clinical Immunology·Hassan AbolhassaniLennart Hammarström
Oct 21, 2016·Scandinavian Journal of Immunology·R YazdaniA Aghamohammadi
Nov 30, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marcela VlkovaZdenek Hel
Oct 3, 2012·Current Opinion in Allergy and Clinical Immunology·Ning Wang, Lennart Hammarström
Jul 4, 2019·Clinical Reviews in Allergy & Immunology·David D Odineal, M Eric Gershwin
Oct 1, 2018·European Journal of Pediatrics·Viviana MoscheseFernando Specchia
May 15, 2018·Frontiers in Immunology·Andri L LemarquisBjorn R Ludviksson
Jul 29, 2020·International Journal of Molecular Sciences·Ida Judyta MaleszaPiotr Eder
May 2, 2020·Clinical & Translational Immunology·Christina Grosserichter-WagenerMenno C van Zelm
May 16, 2019·International Archives of Allergy and Immunology·Yasser BagheriAsghar Aghamohammadi

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