B Lymphocytes and Adipose Tissue Inflammation.

Arteriosclerosis, Thrombosis, and Vascular Biology
Prasad Srikakulapu, Coleen A McNamara

Abstract

The immune system plays an important role in obesity-induced adipose tissue inflammation and the resultant metabolic dysfunction, which can lead to hypertension, dyslipidemia, and insulin resistance and their downstream sequelae of type 2 diabetes mellitus and cardiovascular disease. While macrophages are the most abundant immune cell type in adipose tissue, other immune cells are also present, such as B cells, which play important roles in regulating adipose tissue inflammation. This brief review will overview B-cell subsets, describe their localization in various adipose depots and summarize our knowledge about the function of these B-cell subsets in regulating adipose tissue inflammation, obesity-induced metabolic dysfunction and atherosclerosis.

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Citations

Jan 1, 2021·Arteriosclerosis, Thrombosis, and Vascular Biology·Angelina MisiouColeen A McNamara
Nov 11, 2020·International Journal of Molecular Sciences·Mari T KaartinenKirsi H Pietiläinen
Dec 8, 2020·Frontiers in Cardiovascular Medicine·Ibrahim AlZaimAhmed F El-Yazbi
Mar 9, 2021·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Theocharis KoufakisKalliopi Kotsa
Mar 3, 2021·Genes & Development·Yun Sok Lee, Jerrold Olefsky
Nov 7, 2021·Nature Reviews. Immunology·W V Trim, L Lynch

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