PMID: 15230297Jul 3, 2004Paper

B lymphocytes in systemic lupus erythematosus: lessons from therapy targeting B cells

Lupus
R J LooneyIñaki Sanz

Abstract

Systemic lupus erythematosus (SLE) is a complex disease characterized by numerous autoantibodies and clinical involvement in multiple organ systems. Autoantibodies are usually present in serum for years before the onset of clinical disease. Autoimmunity begins with a limited number of autoantibodies and evolves to become progressively more diverse. Eventually clinical disease ensues. The immunological events triggering the onset of clinical manifestations have not yet been defined. While undoubtedly T cells and dendritic cells appear to play major roles in SLE, a central role for B cells in the pathogenesis of this disease has been brought to the fore in the last few years by work performed both in mice and humans by multiple laboratories. As a result, there is little doubt about the importance of B cells in the development of SLE. Yet much remains to be learned about their role in the ongoing disease process and the merit of targeting B cells for the treatment of SLE. This article will review the role of B cells in human SLE as well as the currently available data on the treatment of SLE by depleting B cells with anti-CD20 (rituximab).

References

Aug 1, 1989·Angiology·A F Heck
Sep 29, 1995·Annals of the New York Academy of Sciences·D F FriedmanL E Silberstein
Sep 1, 1994·Immunology Today·T F Tedder, P Engel
Oct 1, 1993·British Journal of Rheumatology·D IsenbergF Stevenson
Jan 1, 1996·British Journal of Haematology·Y HaradaA Kuramoto
Jan 1, 1996·Blood Cells, Molecules & Diseases·L E SilbersteinT J Kipps
Feb 1, 1997·Rheumatic Diseases Clinics of North America·C E Tseng, J P Buyon
Apr 1, 1998·European Journal of Immunology·T RennoH R MacDonald
Dec 16, 1998·Annals of the Rheumatic Diseases·D A IsenbergF Stevenson
Dec 10, 1999·The Journal of Experimental Medicine·F MackayJ L Browning
Apr 18, 2000·Rheumatic Diseases Clinics of North America·F AndradeA Rosen
Sep 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·U BåveL Rönnblom
Nov 9, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·M OdendahlT Dörner
Dec 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·J ZhangT Zhou
Apr 3, 2001·American Journal of Hematology·B Steinberger, T A Coleman
Apr 3, 2001·American Journal of Hematology·K PatelJ Caro
Aug 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·E ArceV Pascual
Feb 6, 2002·Current Directions in Autoimmunity·Julie Blasioli, Christopher C Goodnow
Apr 12, 2002·Nature·Elizabeth A LeadbetterAnn Marshak-Rothstein
Jul 13, 2002·Arthritis and Rheumatism·Weiqing HuangAnne Davidson
Aug 3, 2002·Nature Immunology·Mikhail B LitinskiyAndrea Cerutti
Sep 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kathleen N PotterBrian J Sutton

❮ Previous
Next ❯

Citations

Oct 12, 2012·Current Allergy and Asthma Reports·Jennifer L RogersTeresa K Tarrant
Apr 27, 2010·Clinical Reviews in Allergy & Immunology·Manuel Ramos-CasalsMunther A Khamashta
Aug 25, 2011·The Proceedings of the Nutrition Society·Leanne C BreslinEmeir M McSorley
Aug 26, 2006·Nature Clinical Practice. Rheumatology·David Isenberg, Anisur Rahman
Mar 3, 2007·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Daitaro Kurosaka
Aug 18, 2004·Current Opinion in Rheumatology·Jennifer Anolik, Iñaki Sanz
Apr 20, 2005·Journal of Immunotherapy·Yulia VugmeysterKathleen McKeever
Dec 29, 2009·Médecine sciences : M/S·Philippe Stas, Ignace Lasters
Feb 13, 2010·Autoimmunity Reviews·Kalina NikolovaAndrey Tchorbanov
Mar 26, 2005·Immunological Reviews·Jens LohrAbul K Abbas
Jan 1, 2008·Arthritis and Rheumatism·R John LooneyLeonard H Calabrese
Nov 24, 2006·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Utako KanekoMakoto Uchiyama
Nov 28, 2008·Arthritis and Rheumatism·Arumugam PalanichamyHans-Peter Tony
Aug 11, 2011·European Journal of Immunology·Nikola S KerekovAndrey I Tchorbanov
Feb 16, 2010·British Journal of Haematology·Nichola Cooper, Donald M Arnold
Dec 28, 2005·The American Journal of Medicine·Bertrand L Jaber, Nicolaos E Madias
Oct 3, 2006·Current Opinion in Immunology·Lucienne Chatenoud
Aug 3, 2005·Immunology Letters·Elena Peeva, Moncef Zouali
Jun 24, 2015·Current Opinion in Pharmacology·Lucienne Chatenoud
Mar 1, 2005·Lupus·H Tahir, D A Isenberg
Jul 1, 2014·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Toshiyuki Bohgaki, Tatsuya Atsumi
Jan 5, 2016·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Shigeru Iwata, Yoshiya Tanaka
Oct 16, 2018·Journal of Neuroscience Research·Madhuri WanvePallab Bhattacharya
Jan 20, 2011·Pharmacological Reviews·Pablo EngelXavier Bosch
Jul 1, 2017·Expert Opinion on Biological Therapy·Dejan JakimovskiRobert Zivadinov
Nov 22, 2017·Turkish Journal of Medical Sciences·Emine Nur ÖzdamarHakkı Gürsöz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.