PMID: 9428611Jan 15, 1998Paper

B-Myb, a repressed trans-activating protein

Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte
S AnsieauA Leutz

Abstract

B-Myb belongs to a family of related transcription factors which share a unique DNA binding domain. B-Myb plays an important role in regulation of the cell cycle. Its expression is upregulated by the human papilloma virus HPV16 E7 oncoprotein. Overexpression of B-Myb can bypass p53-mediated cell cycle arrest. The founding member of the myb gene family, c-Myb, and A-Myb are involved in hematopoiesis and neurogenesis, respectively, and are both activators of gene transcription. Whether B-Myb is a transactivator or a repressor, however, has remained a matter of discussion. We reviewed the transactivation potential of B-Myb in yeast, taking advantage of the fact that inducible gene activation is an evolutionarily conserved process. By mutational analysis we localized a conserved activation domain in B-Myb. In vertebrate cells the transactivation potential of B-Myb is concealed by the C-terminal part of the protein. We show that the cell cycle regulators cyclin A and cyclin E activate B-Myb by eradicating the inhibition mediated by its carboxy-terminus. Our data suggest that in vertebrates the trans-activating function of B-Myb is regulated during the cell cycle and link Myb functions to cell cycle progression.

Citations

Dec 15, 2011·The Journal of Biological Chemistry·Chao-Cheng ChoChin-Hung Sun
Jan 29, 2011·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Katharine AstburyJohn J O'Leary
Jun 29, 1999·Cold Spring Harbor Symposia on Quantitative Biology·B J GravesM E Gillespie
Jun 4, 2011·Best Practice & Research. Clinical Obstetrics & Gynaecology·Cara M Martin, John J O'Leary
Mar 22, 2001·Blood Cells, Molecules & Diseases·M BessaR J Watson
May 31, 2017·International Journal of Molecular Sciences·Yuelei JinYouquan Bu
Jul 12, 2013·Nature Reviews. Cancer·Subhashini Sadasivam, James A DeCaprio
May 19, 2018·International Journal of Molecular Sciences·Xiaoyan FanYouquan Bu
Dec 15, 2000·Oncogene·S HorstmannK H Klempnauer
Apr 20, 2000·The Journal of Biological Chemistry·M CervelleraA Sala
Dec 25, 2004·The Journal of Biological Chemistry·Giorgia SantilliArturo Sala
Mar 30, 1999·European Journal of Biochemistry·O BartschS Ferrari

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