B Regulatory Cells: Players in Pregnancy and Early Life

International Journal of Molecular Sciences
Ana Esteve-SoléLaia Alsina

Abstract

Pregnancy and early infancy represent two very particular immunological states. During pregnancy, the haploidentical fetus and the pregnant women develop tolerance mechanisms to avoid rejection; then, just after birth, the neonatal immune system must modulate the transition from the virtually sterile but haploidentical uterus to a world full of antigens and the rapid microbial colonization of the mucosa. B regulatory (Breg) cells are a recently discovered B cell subset thought to play a pivotal role in different conditions such as chronic infections, autoimmunity, cancer, and transplantation among others in addition to pregnancy. This review focuses on the role of Breg cells in pregnancy and early infancy, two special stages of life in which recent studies have positioned Breg cells as important players.

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Citations

Sep 20, 2019·Pediatric Research·Dajana Sabic, Joyce M Koenig
Nov 25, 2018·Genome Medicine·Steven Schaffert, Purvesh Khatri
May 3, 2020·Neurology. Neuroimmunology and Neuroinflammation·Jessica B SmithAnnette Langer-Gould
Aug 9, 2020·Frontiers in Pediatrics·Kristen M MerinoMarcelo J Kuroda
Jan 9, 2019·Frontiers in Physiology·Rafael Tomoya MichitaJosé Artur Bogo Chies
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Jul 19, 2020·International Immunopharmacology·Roghayeh JafarpourMorteza Motallebnezhad
Jun 3, 2021·International Journal of Molecular Sciences·Sarah Cunningham, Holger Hackstein
Aug 28, 2021·Frontiers in Cell and Developmental Biology·Mengni ShenJennifer H Southcombe

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