B-type natriuretic peptide levels and cardiovascular risk in patients with diastolic dysfunction on chronic haemodialysis: cross-sectional and observational studies

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Hiroyuki TakaseGenjiro Kimura

Abstract

Elevated B-type natriuretic peptide (BNP) levels are predictive of cardiovascular events in patients on chronic maintenance haemodialysis, even in those without apparent cardiovascular disorders when they start dialysis. In the present study, we tested the hypothesis that left ventricular diastolic dysfunction increases BNP levels and can predict cardiovascular events in patients on chronic haemodialysis without apparent cardiac disease. Patients on chronic maintenance haemodialysis in a stable condition and with normal systolic function were enrolled (n=98). BNP concentrations were measured, and left ventricular diastolic function was assessed using echocardiography after the first dialysis session of the week. Then, they were followed up for 2 years with the end point being the incidence of cardiovascular events. At baseline, left ventricular diastolic dysfunction was detected in 39 of 98 patients. After adjustment for known risk factors, multivariable regression analysis demonstrated that diastolic dysfunction was a significant predictor of increased BNP levels (P<0.05). During the follow-up period, 17 patients experienced cardiovascular events. Kaplan-Meier analysis demonstrated that the incidence of cardiovascular events w...Continue Reading

References

Dec 23, 1971·The New England Journal of Medicine·P A McKeeW B Kannel
Nov 20, 1998·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·R N FoleyM J Sarnak
Apr 24, 1999·Journal of the American Society of Nephrology : JASN·J Q Jaeger, R L Mehta
Oct 17, 2002·American Journal of Nephrology·Toshihide NaganumaTatuya Nakatani
Apr 16, 2003·The American Journal of the Medical Sciences·Allan J Collins
Feb 7, 2004·European Journal of Clinical Investigation·H TakaseY Dohi
Feb 13, 2004·The New England Journal of Medicine·Thomas J WangRamachandran S Vasan
May 28, 2004·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Shimon A ReisnerZvi Friedman
Oct 2, 2004·International Journal of Cardiology·Paavo UusimaaUNKNOWN Anglo-Scandinavian Cardiac Outcomes Trial Investigators
Sep 27, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Susan VickeryEdmund J Lamb
Oct 14, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Patrick B MarkAlan G Jardine
Apr 29, 2006·Nephron. Clinical Practice·Jaroslav RacekJaromír Eiselt
May 5, 2006·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Hidetaka ShimadaKimio Tomita
May 11, 2006·Journal of Hypertension·Giovanni TripepiCarmine Zoccali
Jun 13, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Akihiko TakahashiYasuaki Dohi
Oct 4, 2006·Hemodialysis International·Ingegerd Odar-CederlöfCarl M Kjellstrand
Mar 16, 2007·Journal of the American Society of Nephrology : JASN·Giovanni TripepiCarmine Zoccali
Mar 22, 2007·European Journal of Clinical Investigation·H TakaseY Dohi
Mar 12, 2008·European Journal of Heart Failure·Jasmine GrewalHans Persson
Sep 3, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Shinichiro NiizumaHajime Nakahama

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.