B-Vitamin Intake from Diet and Supplements and Breast Cancer Risk in Middle-Aged Women: Results from the Prospective NutriNet-Santé Cohort

Nutrients
Manon EgnellMathilde Touvier

Abstract

Experimental studies suggest a protective effect of B-vitamins on breast cancer risk, potentially modulated by alcohol intake. However, epidemiological studies are limited, especially regarding non-folate B-vitamins. Furthermore, few studies included quantitative assessment of supplemental intake. This prospective study aimed to investigate the associations between intakes of B-vitamins (dietary, supplemental, total) and breast cancer risk. 27,853 women aged ≥45 years from the NutriNet-Santé cohort (2009-2016) were included, with a median follow-up time of 4.2 years. Dietary data were collected using repeated 24 h records. A specific questionnaire assessed dietary supplement use over a 12-month period. A composition database of 8000 supplements was developed. Associations were characterized by multivariable Cox models, and 462 incident breast cancers were diagnosed. Dietary (HRQ4vs.Q1= 0.74 (0.55, 0.99),P-trend = 0.05), supplemental (HRQ4vs.Q1= 0.61 (0.38, 0.98),P-trend = 0.05), and total (HRQ4vs.Q1= 0.67 (0.50, 0.91),P-trend = 0.01) pyridoxine intakes were inversely associated with breast cancer risk. Total thiamin intake was borderline inversely associated with breast cancer risk (HRper 1-unit increment= 0.78 (0.61, 1.00),P= ...Continue Reading

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Citations

Jan 22, 2019·Current Breast Cancer Reports·Annina SeilerChristopher P Fagundes
Jul 29, 2020·Digestive Diseases and Sciences·Satoko OhfujiWakaba Fukushima
Dec 3, 2021·Nutrition and Cancer·José Reginaldo Alves de Queiroz JúniorCarina Scanoni Maia

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