B-vitamin intake, one-carbon metabolism, and survival in a population-based study of women with breast cancer.

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Xinran XuJia Chen

Abstract

Breast cancer is the second leading cause of cancer mortality among women. Given its important role in DNA methylation and synthesis, one-carbon metabolism may affect breast cancer mortality. We used a population-based cohort of 1,508 women with breast cancer to investigate possible associations of dietary intake of B vitamins before diagnosis as well as nine polymorphisms of one-carbon metabolizing genes and subsequent survival. Women newly diagnosed with a first primary breast cancer in 1996 to 1997 were followed for vital status for an average of 5.6 years. Kaplan-Meier survival and Cox proportional hazard regression analyses were used to evaluate the association between dietary intakes of B vitamins (1,479 cases), genotypes ( approximately 1,065 cases), and all-cause as well as breast cancer-specific mortality. We found that higher dietary intake of vitamin B(1) and B(3) was associated with improved survival during the follow-up period (P(trend) = 0.01 and 0.04, respectively). Compared with the major genotype, the MTHFR 677 T allele carriers have reduced all-cause mortality and breast cancer-specific mortality in a dominant model [hazard ratio (95% confidence interval): 0.69 (0.49-0.98) and 0.58 (0.38-0.89), respectively]. ...Continue Reading

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Citations

May 7, 2010·Journal of Inherited Metabolic Disease·Per Magne Ueland
Nov 19, 2009·Breast Cancer Research and Treatment·Xinran XuJia Chen
Nov 1, 2011·Breast Cancer Research and Treatment·Holly R HarrisAlicja Wolk
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Mar 1, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Xinran XuJia Chen
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